Zollinger-Ellison syndrome, treatment

Less common causes of peptic ulceration include Zollinger-Ellison syndrome (ZES), cancer chemotherapy, radiation, and vascular insufficiency. ZES is caused by a gastrin-producing tumor called a gastrinoma and results in gastric acid hypersecretion. High-dose oral proton pump inhibitor (PPI) therapy is the initial treatment of choice for ZES intermittent intravenous PPI therapy may be required for any patient in whom oral therapy is contraindicated.1... 

Ranitidine is a histamine receptor antagonist. It acts essentially on the H2 receptor and blocks acid production. Ranitidine is used in the treatment and prevention of ulcers, NSAID-induced ulcers, Zollinger-Ellison syndrome and gastro-oesophageal reflux disease. 

Raoul JL, Bretagne JF, Ropert A, Siproudhis L, Heresbach D, Gosselin M. Zollinger-Ellison syndrome, antisecretory treatment, and body weight. Dig Dis Sci 1992 37(8) 1308-9. 

Clinical use Treatment of dyspepsia, gastroduodenal ulcers, gastroesophageal reflux disease (GERD), and Zollinger-Ellison syndrome. 

Erosive esophagitis . 10 mg Zollinger-Ellison syndrome fiO mg NSAID-induced gastric ulcers treatment and prevention Dosage form Delayed-relea.se capsules containing 15 and. 10 mg of lansoprazole in enteric-coated granules... 

Ranitidine is indicated for therapy of peptic ulcer disease, gastroesophageal reflux disease, pathological hypersecretory conditions (e.g., Zollinger-Ellison syndrome), erosive esophagitis, and adjunctive treatment of acute allergic reactions. 

Zollinger-Ellison Syndrome — Cimetidine also blocks acid output in Z-E patients without causing side effects.This use of an -receptor antagonist, shown earlier for metiamide,represents an important advance in the treatment of this peptic ulcer disease condition. 

Omeprazole effectively inhibits gastric secretion by inhibiting the gastric H+, K+-ATPase. " This enzyme is responsible for gastric acid production and is located in the secretory membranes of parietal cells. Thus, omeprazole is proposed as an anti-ulcerative drug, specially in the treatment of Zollinger-Ellison syndrome. " ... 

Famotidine (40 mg once a day at bedtime) is indicated for the short-term (4 weeks) treatment of active duodenal ulcer as maintenance therapy for duodenal ulcer at reduced dosage after healing has taken place for shortterm treatment of gastroesophageal reflux disease and in the treatment of hypersecretory conditions such as Zollinger-Ellison syndrome or multiple endocrine adenoma. Famotidine, which is a competitive inhibitor of H2 receptors, inhibits gastric secretion. It is absorbed incompletely (40 to 50%), metabolized partly to an S-oxide metabolite, and partly is excreted unchanged in the urine (see also Table 10 and Figure 23). 

THERAP CAT Anti -ulcerative in treatment of Zollinger-Ellison syndrome. 

Lloyd-Davies KA, Rutgersson K, Solved L (1988) Omeprazole in the treatment of Zollinger-Ellison syndrome a 4-year international study. Aliment Pharmacol Ther 2 13-32... 

Hirschowitz BI, Denen J, Raufman J, LaMont B, Berman R, Humphries T (1988) A multicenter US study of omeprazole treatment of Zollinger-Ellison syndrome. Gastroenterology 94 A188 (abstract)... 

Bonfils S, Mignon M, Gratton J (1979) Cimetidine treatment of acute and chronic Zollinger-Ellison syndrome. World JSurg 597-604... 

Deveney CW, Stein S, Way LW (1983) Cimetidine in the treatment of Zollinger-Ellison syndrome. Am J Surg 146 116-123... 

Vezzadini P, Bonora G, Tomassetti P, Pazzaglia M, Labo G (1983) Medical treatment of Zollinger-Ellison syndrome with ranitidine. IntJTiss Reac 4 339-343... 

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