Zine chloride

To elucidate the nature of the product and confirm the postulated copolymerization, the reaction of isoprene and butadiene with acrylonitrile in the presence of zinc chloride was investigated. In the absence of solvent or in the presence of a small amount of benzene, the addition of a small amount of isoprene to an equimolar mixture of acrylonitrile and zine chloride results in spontaneous polymerization, and the solution turns orange. 

SYNS ACTOZINE AMIOYL AMISYL AMITAKON AMIZIL HYDROCHLORIDE ARCADINE AY-5406 BENACTIZINE HYDROCHLORIDE BENACTYZIN (CZECH) BENACTY-ZINE CHLORIDE BENACTYZINE HYDROCHLORIDE... 

In the paste type, the paste is dispensed into the zine ean. The preformed bobbin (with the carbon rod) is inserted, pushing the paste up the ean walls between the zine and the bobbin by displacement. After a short time, the paste sets or gels. Some paste formulations need to be stored at low temperatures in two parts. Tbe parts are then mixed they must be used immediately as they can gel at room temperature. Other paste formulations need elevated temperatures (60°C to 96°C) to gel. The gelatinization time and temperature depend upon the concentration of the electrolyte constituents. A typical paste electrolyte uses zine chloride, ammonium chloride, water, and starch and/or flour as the gelling agent. 

Acylation of norephedrine (56) with the acid chloride from benzoylglycolic acid leads to the amide (57), Reduction with lithium aluminum hydride serves both to reduce the amide to the amine and to remove the protecting group by reduction (58), Cyclization by means of sulfuric acid (probably via the benzylic carbonium ion) affords phenmetrazine (59), In a related process, alkylation of ephedrine itself (60) with ethylene oxide gives the diol, 61, (The secondary nature of the amine in 60 eliminates the complication of dialkylation and thus the need to go through the amide.) Cyclization as above affords phendimetra-zine (62), - Both these agents show activity related to the parent acyclic molecule that is, the agents are CNS stimulants... 

Acenaphtheno[l,2-e][l,2,4]triazolo[4,3-h][l,2,4]triazine 747 was prepared (79AP147) by cyclizing 3-hydrazinoacenaphtheno[l,2-e][l,2,4]tria-zine 746 with formic acid. Reaction of 746 with sugars gave the hydrazones, which cyclized with iron(III) chloride to give 748 (93BCJ00). Similarly, the acetaldehyde derivative of 746 was cyclized to 748. The structure of 748 (R = Me) rather than 747 (R = Me) was deduced by unequivocal synthesis of the latter by condensation of acenaphthenequinone with 3,4-diamino[l,2,4]triazole (Scheme 155). 

Alternatively, reaction of methyl 4-cyanobenzimidate 88 with picolinoyl chloride 92a or 6-methylpicolinoyl chloride 92b delivered the intermediates 93. The subsequent reaction of imidates 93 with 4-methoxyphenylhydra-zine gave 1,2,4-triazoles 94a and 94b (Equation 34) <2004BMC2013>. 

A novel heterocyclic system has been achieved from methyl 3-aminopyra-zine-2-carboxylate and several aroyl chlorides, leading to 3-aroylamino derivatives the latter are cyclized with dibromotriphenylphosphorane to 2-arylpyrazino[2,3-rf][3,l]oxazin-4-one (94S405). Furthermore, vinylimino-phosphoranes and diphenylketene react (Scheme 87) to give nonisolable vinylketenimines (233) which afford, with a second equivalent of ketene in a [4 + 2]-cycloaddition, 1,3-oxazinones (234) [89JCS(P1)2140]. 

Complexes are also known in which the co-ordination numbers- are one, two, three, five, seven, and even eight respectively, but these are less frequent. As examples may be mentioned sulphito-coppcr potassium, [Cu(S03)]K, and the unstable nitroso-ferrous sulphate, [Fe(N0)]S04, each of which possess unit co-ordination number. l)i-ammino-silvcr chloride, [Ag(NH3)2]Cl, and triammino-silver chloride. [Ag(NIT3)3]Cl, possess co-ordination numbers two and three respectively. In penta-phenylhydrazino-zine sulphate, [Zn(NHa.NH.C6II5)5JS04, and octammino-strontium chloride, [Sr(NH3)8]Cl2, the co-ordination numbers are five and eight respectively. 

Figure 4. Profiles of volatiles for high-quality peanuts, raw and roasted (1) ethanol (2) pentane (3) 2-propanol (4) acetone (5) methylene chloride (6) methyl acetate (7) 2-methylpropanal (8) diacetyl (9) 3-methylbutanal (10) 2-methyl-butanal (11) 2,3-pentanedione (12) S-methylpyrrole (13) toluene (14) hexanal (15) 2-methylpyrazine (16) xylene (17) 2-heptanone (18) 2,5-dimethylpyrazine (19) 2-pentylfuran (20) 2-ethyl-5-methylpyrazine (21) 2-ethyl-3,6-dimethylpyra-zine (22) phenylacetaldehyde.

Sexavalent sulphur is the most stable form of combined sulphur. Various hydroxy-derivatives are known. The lowest is the unisolated sulphoxylic acid, H2S02, of which the zine salt has been obtained by the action of zinc dust on an ether solution of sulphuryl chloride.1... 

Chloro derivative 291 was obtained from dioxo derivative 70 by treatment of phosphoryl chloride in dimethylformamide at 100°C for 2 hours (80CPB3537). The treatment of chloro derivative 291 with methylhydra-zine in a mixture of ethanol and chloroform under reflux gave 2H-pyrido[ 1,2-a]pyrimidin-2-one 295 and rearranged pyridazino[3,4-6]-quinoxaline 296 in 4.8% and 78% yields, respectively (Scheme 21) (80CPB3537). 3,4-Dihydroquinoxalinone 70 could not be rearranged into pyridazino[3,4-6]quinoxaline 296 by treatment with methylhydrazine. When hydrazine hydrate was employed instead of methylhydrazine, tricyclic ethyl ester 297 (R1 = Et) was obtained. The latter reaction gave methyl ester 297 (R1 = Me) when carried out in a mixture of methanol and chloroform (80CPB3537). 

Metal-Complex (Formazan) Dyes. The hydrazone from 2-carboxyphenylhydra-zine-4-sulfonic acid and benzaldehyde is suspended in water and then dissolved by adding aqueous sodium hydroxide to obtain pH 6.5 -7.0. This solution is added to the aqueous diazonium salt solution obtained from a typical aqueous diazotiza-tion of 4-(2-sulfooxyethylsulfonyl)-2-aminophenyl-6-sulfonic acid. The mixture is then dripped into an aqueous solution of copper sulfate, while the pH is maintained with soda at 5.5 - 6.5. After complete coupling the pH is adjusted to 1 with concentrated hydrochloric acid. The strongly acidic solution is then neutralized with alkali to pH 5.5. The copper - formazan complex is salted out along with sodium chloride, filtered, washed with dilute aqueous sodium chloride solution, and dried. A dark powder results which gives a dark blue solution in water. It consists of an electrolyte-containing powdered sodium salt of the acid 25 ... 

This is the case for instance of imidazoles, triazoles, and tria-zines derived from cyanuric chloride among others. 

H2-labelled thioridazine 56 (the phenothiazine-type antipsychotic agent) has been obtained recently39 for metabolic and pharmacokinetic studies by a new route (equation 16) from 2-(2-hydroxyethyl)piperidine 57. The key steps in this sequence of reactions involve ruthenium tetroxide oxidation of the 7V,0-diacetylated starting material 58 and subsequent lithium aluminium deuteride reduction of the 2-(2-acetoxyethyl)-6-piper-idinone (59, R = Ac). Treatment of 60 with thionyl chloride produced 2-(2-chloroethyl)-l-methyl[6,6-2H2]piperidine which, on N(10)-alkylation of 2-methylthio-10i/-phenothia-zine, yielded 56. For each of the seven steps in the conversion of 57 to 56 the yield has been at least 76%40. 

Clomipramine is the imipramine analogue of chlorproma-zine. However, while the difference between chlorproma-zine and promazine is large, adding a chloride atom to imipramine hardly affects its actions. Most trials have failed to show any superiority of the chlorinated compound over imipramine. The adverse effects profile is similar (1), but drowsiness, confusion, and feeling awful are commonly reported (2). 

DEHALOGENATION Alumihum chloride-Ethanethiol. Sodium sulfide. Zine borohydride. 

Unexpectedly, phenothiazine with sulfonyl chlorides in the presence of AICI3 yields only 3-monosulfonyl derivatives (119). Probably, 10-sulfonyl derivatives (118) are intermediates which subsequently rearrange. 10-Sulfonyl derivatives are rearranged by AlClg into 3-sulfonyl derivatives, and 10-benzenesulfonylphenothia-zine with tosyl chloride gives only 3-benzenesulfonylphenothiazine. 

The. smoke ntixtiire was < ompo ed of hcxachloretliane, powdt-red zine, ummoniiim perchlorate, and ammonium chloride, and the starting mixture oon.si.sted of potassium nitrate, antimony trisulfido, and dextrine. 

AMINO GROUP Boron trifluoride ether-ate. 1-/-B utyloxy carbony ltriazole-1,2,4. Di-f-butyl dicarbonate. 4-Dimethylamino-1-f-butyloxycarbonyl pyridinium chloride. CARBONYL GROUP Ceric ammonium nitrate. 1,2-Dihydroxy-3-bromopropane. Sodium N-chloro-p-toluenesulfonamide. Thallium(III) nitrate. Trichloroethanol. Trimethylsilyl cyanide. Chloromethyl methyl sulfide. N,N -Diisopropylhydra-zine. Trichloroethanol. 

Pyrrole reacts with malonamides in phosphoryl chloride giving pyrroli-zines in moderate yields (Scheme 6).15 Benzimidazole-2-propionic acid undergoes cyclization and subsequent formylation under Vilsmeier conditions at room temperature (RT) (Scheme 7).16... 

Acylation of the amino group at the 4-position of 3,4,5-triaminothiadia-zine 10b with trifluoroacetic acid, and with acetyl, benzoyl, caproyl, and p-toluenesulfonyl chloride, has been described (86FES862). The 4-aryl-diazonium salts have also been prepared (77JHC427), Reactions of 4,5-diaminothiadiazines are described with regard to the preparation of fused systems in Section II,C,2,a. 

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