Zanthoxylum simulans

Ko FN, Chen IS, Wu SJ, Lee LG, Haung TF, Teng CM. Antiplatelet effects of chel-erythrine chloride isolated from Zanthoxylum simulans. Biochim Biophys Acta 1990 1052 360-365. 

Sichuan pepper Zanthoxylum simulans Linalool, a-hydroxysanshool 164... 

The benzophenanthridine alkaloid chelerythrine (37) isolated from Zanthoxylum simulans (Rutaceae) is a potent, selective antagonist of PKC from rat brain (IC50 = 0.66 pM). Inhibition was competitive with respect to the phosphate acceptor (histone Ills) and non-competitive with respect... 

Zanthoxylum simulans Hance SCN Sichuan pepper PN hua jiao (pericarp)... 

Ko, F.N., I.S. Chen, S.J. Wu, et al. 1990. Antiplatelet effects of chelerythrine chloride isolated from Zanthoxylum simulans. Biochim. Biophys. Acta 1052(3) 360-365. 

Zanthoxylum schinifolium fruit pericarp Zanthoxylum simulans fruit pericarp Ziziphus jujuba var. spinosa seed... 

Chen IS, Wu SJ, Leu YL, Tsai IW, Wu TS. Alkaloids from root bark of Zanthoxylum simulans. Phytochemistry 1996 42 217-9. 

Among some other quinoline alkaloids, N-methylflindersine was isolated firom rutaceous plants such as O. japonica and Fagara chalybea and showed antifeedant activity against insects Spodoptera exempta) [10]. Eduli-nine, on the other hand, isolated from Zanthoxylum simulans (Rutaceae), was shown to possess analgesic and anticonvulsive activities [11]. 

Another Rutaceous plant with a similar alkaloidal spectrum to rue is prickly ash bark—Zanthoxylum spp. Two new quinoline alkaloids isolated from Zanthoxylum simulans were shown to have cytotoxic and antiplatelet activities (Chen et al. 1994). 

A-Acetoxymethylflindersine III I-CH2OAC Haplophyllum suaveolens [34], Zanthoxylum simulans [27]... 

Zanthoxylum simulans, a shrub found in China (Scheme 12.18). Simulenoline 84 and a third pyranoquino-line alkaloid, zanthodioline 86, from the same species were disclosed [51]. These novel monoterpenoid pyranoquino-lines are potent inhibitors of platelet aggregation [51]. Only huajiaosimuline 85 is toxic toward several human cultured cell lines, especially the estrogen receptor-positive breast cancer cells, ZR-75-1 [53]. 

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