Zanasi capsule-filling machine

Fig. 11 Zanasi Matic 90 automatic capsule-filling machine. (Courtesy of IMA North America, Inc., Fairfield, CT.)... 

Fig. 16 Typical force-time trace from an instrumented Zanasi LZ-64 automatic capsule-filling machine. PC, precompression resulting from dipping of dosator into the powder bed C, compression resulting from actual piston tamping R, retention force Ej, ejection D, drag force developing during retraction of piston. (From Ref. 38.)...

Fig. 17 Effect of powder bed height, piston height, and compression force on plug ejection force in an instrumented Zanasi LZ-64 automatic capsule-filling machine (pregelatinized starch lubricated with 0.005% magnesium stearate). Note that the first point of each curve is precompression. Piston height (mm) , 15 -jlf, 14 , 13 , 12. Powder bed height (mm) heavy line, 30 light line, 50. (From Ref. 51.)...

Piezoelectric transducers have also been used to instrument automatic capsule filling machines. Mony et al. [72] instrumented a Zanasi RV/59 by fitting a piezoelectric load cell to the upper end of a piston. This... 

Cole GC, May G. The instrumentation of a Zanasi LZ/64 capsule filling machine. J Pharm Pharmacol 1975 27 353-358. 

Development product Capsule product containing x mg of drug y ( freely water soluble ) and 1% magnesium stearate was developed using a Zanasi LZ-64 capsule-filling machine. Initial development experiments identified a causal link between blend time and dissolution rate. Capsules prepared with powders blended for 5 minutes exhibited a more rapid dissolution rate ( 95% dissolved in 10 minutes) compared to powders blended for 40 minutes ( 90% dissolved in 45 minutes). A 10-kg lot was blended for 15 minutes in a V-blender. Under these conditions the resulting capsules conformed to an in vitro dissolution acceptance criteria of Q75% in 45 minutes (in 900 mL water at 37°C, USP Basket 100 rpm). 

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