Yeast ABC protein

Decottignies A, Goffeau A (1997) Complete inventory of the yeast ABC proteins. Nat Genet 15 137-145... 

ABC proteins (so far) is the yeast ABC protein Mdll [119], where studies of... 

Figure 6.1 Predicted topology and domain organization of fungal ABC protein subfamilies. The figure depicts the predicted membrane topology and domain organization of all subfamilies encoding yeast ABC proteins (see text for details). NBD, nucleotidebinding domain NTE, N-terminal extension TMS, transmembrane segment.

Nichols, f.W., de Wet, H., McIntosh, D.B., and Goffeau, A. (1998) ATPase and multidrug transport activities of the overexpressed yeast ABC protein Yorlp. The Journal of Biological Chemistry, 273, 12612-12622. 

Bauer, B.E., Wolfger, H., and Kuchler, K. (1999) Inventory and function of yeast ABC proteins about sex, stress, pleiotropic drug and heavy metal resistance. Biochimica et Biophysica Acta, 1461, 217-236. 

Ortiz, D.R, Ruscitti, T., McCue, K.F., and Ow, D.M. 1995. Transport of metal binding peptides by HMT-1, a fission yeast ABC type vacuolar membrane protein. Journal of Biological... 

Berkower, C., and Michaelis, S. (1991). Mutational analysis of the yeast a-factor transporter STE6, a member of the ATP binding cassette (ABC) protein superfamily. EMBO J 10 3777-3785. 

Wolfger, H., Mamnun, Y.M., and Kuchler, K. (2004) The yeast PdrlSp ATP-binding cassette (ABC) protein is a general stress response factor implicated in cellular detoxification. The Journal of Biological Chemistry, 279, 11593-11599. 

Two additional ABC transporters in yeast, Auslp (the acronym derives from ABC protein involved in uptake of sterols) and Pdrl Ip, are upregulated in response to growth of cells on sterols, and are required for transporting extracellular sterols to the ER for the synthesis of steryl esters [21]. 

Interestingly, if organisms contain non-Bi2 cobalt enzymes such as nitrilases (Koba-yashi and Shimizu 1998), an additional slow, chemisosmotically driven uptake system (NiCoT protein family) is co-expressed with the enzyme (Komeda et al. 1997). ATP-hydrolyzing uptake systems for cobalt (e.g., ABC-transport systems) are not known. This indicates that cobalt for B12-enzymes may indeed be imported as cobalamin, Co(II) for other enzymes by NiCoT transport systems and that Co(II)-import by other systems may not be important in the natural environment of the cells. Co(II) is of medium toxicity and is detoxified by efflux systems (CDF protein family, RND-driven CBA-export systems) in bacteria and yeasts (Nies 2003). 

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