Polychelating polymers

Erdogan S et al (2006) Gadolinium-loaded polychelating polymer-containing cancer cell-specific immunoliposomes. J Liposome Bes 16 45-55... 

Erdogan S, Roby A, Torchilin VP (2006) Enhanced tumor visualization by gamma-scintigraphy with lllln-labeled polychelating-polymer-containing immunoliposomes. Mol Pharm 3 525-530... 

Gadolinium-Loaded Polychelating Polymer-Containing lUmor-Targeted Liposomes... 

Erdogan, S., Roby, A., Torchilin, V.P., 2006. Enhanced tumour visualization by y-scintigraphy with In-labeled polychelating-polymer-containing immunoliposomes. Molecular Pharmaceutics 3, 525—530. 

PDP-N-terminally modified DTPA- polylysine Figure I. Synthesis of terminus-activated polychelating polymer (DTPA-PLL),... 

A subsequent single-point attachment of the polychelating polymer to an antibody (or antibody fragment, Fab) may be completed using various different routes via such reagents as SPDP, succinimidyl maleidomethyl cyclohexane (SMCC) or by bromoacetylation as shown in Figure 2. ... 

POLYCHELATING AMPHIPHILIC POLYMERS (PAP) AS KEY COMPONENTS OF MICROPARTICULATE DIAGNOSTIC AGENTS... 

Polychelating Amphiphilic Polymers (PAP) as Key Components of Microparticulate Diagnostic Agents... 

The first method used a Pauling-Erdeli-Pauling thermobalance at temperature intervals between 20° and 700°C in an inert medium. The temperature was raised 12.4°C per minute, the results being compared with those of the standard polymer. With a Fe3+ complex synthesized for 96 hours, the polychelate reached a maximum loss of only 28 at 440°C and often showed a constant thermal stability. Unmodified polyethylene terephthalate continually lost weight showing a loss of 95.9 at 577°C. 

Table IV contains some comparative data regarding the electrical conductivity of some polychelates based on Fe3+ and Mn2+. The data dealing with electrical conductivity of polychelates, the starting polymers (for polyethylene terephthalate,

Phthalocyanine complexes, deposited as a film on a metal of the same kind as their central metal ion, appeared to be active for hydrazine decomposition 48)-Wholly organic polymers, prepared by the dechlorination of poly vinylidene chloride 62> were also shown to be active, but the ammonia and hydrogen produced reacted with the catalyst, a problem also encountered with the polychelate catalysts. 

One common possibility for the preparation of low molecular hemiporphyrazines is starting from o-dicyano compounds sudi as 1,2-dicyanbenzene and diamines sudi as 1,4-diaminobenzene or 2,6-diaminopyridine to obtain the ligand followed by introduction of metal ions (in the case using diaminopyridine) In order to get polymers, concepts of bifunctionality with various tetracyano compounds 103) and diamines 104) were used to prepare the polymer ligand 105)-, this is in some cases able to form polychelates 106) (Eq. 57, Table 17). 

The structures of all products (I13)- H7) were determined by UVATS, IR and mass spectra. However, the dark coloured polymers are insoluble in organic solvents. Therefore no molecular weight determination was possible. The thermal decomposition of the polychelates starts under N2 at 700 K. At 1070 K wei t loss is 10% ... 

If the polymer ligands (125), (126) are soluble in polar solvents like DMAc or DMF route a) is the best decision. By adding metal salts, the polychelates are precipitated. Also structure investigation is easier wifli polymer ligands than with insoluble polychelates. Route b) may be choosen if the polymer ligand is insoluble because quantitative introduction of metal ion using route a) may be without success. 

Tl(rV), V(IV), In(III) led to the polychelates (125M), (126M). If the degree of polycondensation is not too high, the yellow polymer ligands are soluble in polar solvents. The intensively coloured polychelates are insoluble. 

Main research interest until now was getting informations about thermal stability of polymer N202-chelates285,287,290,2931295-2981300. In air or nitrogen the decomposition of the polychelates mainly occurs between 520 and 720 K. The thermal stability of the polychelates (126 M) depends on the following parameters. 

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