Y-Aminobutyric acid transporters

Kanner, B.I. Bendahan, A. (1990). Two pharmacologically distinct sodium- and chloride-coupled high affinity y-aminobutyric acid transporters are present in plasma membrane vesicles and reconstituted preparations from rat brain. Proc. Natl. Acad. Sci. USA 87,2550-2554. 

Kanner, B.I., Keynan, S Radian, R. (1989). Structural and functional studies on the sodium-and chloride-coupled y-aminobutyric acid transporter Deglycosylation and limited proteolysis. Biochemistry 28, 3722-3728. 

Mabjeesh, N.J. Kanner, B.I. (1992). Neither amino nor carboxyl termini are required for function of the sodium- and chloride-coupled Y-aminobutyric acid transporter from rat brain. J. Biol. Chem. 267,2563-2568. 

Pantanowitz, S Bendahan, A., Kanner, B.l. (1993). Only one of the charged amino acids located in the transmembrane a-helices of the y-aminobutyric acid transporter (Subtype A) is essential for its activity. J. Biol. Chem. 268,3222-3225. 

Lopez-Corcuera B, Liu Q-R, Mandiyan S, Nelson H, Nelson N (1992) Expression of a mouse brain cDNA encoding novel y-aminobutyric acid transporter. J. Biol. Chem., 267, 17491-17493. 

Mabjeesh N, Frese M, Rauen T, Jeserich G, Kanner BI (1992) Neuronal and glial y-aminobutyric acid+ transporters are distinct proteins. Fed. Ear Biochem. Soc., 299, 99-102. 

Radian, R., et al. (1986). Purification and Identification of the Functional Sodium- and Chloride-coupled y-aminobutyric Acid Transport Glycoprotein from Rat Brain, J. Biol. Chem. 261 15437-15441. 

Stensrud MJ, Chaudhry FA, Leergaard TB et al (2013) Vesicular glutamate transporter-3 in the rodent brain vesicular colocalization with vesicular y-aminobutyric acid transporter. J Comp Neurol 521 3042-3056... 

Mechanism of Action The mechanism of action of divalproex is not well understood. It is known to affect ion transport and enhances the activity of y-aminobutyric acid. Like lithium, it also has possible neuroprotective effects through enhancement of brain-derived neurotrophic factor.31... 

Bismuth, Y., Kavanaugh, M. P., and Kanner, B. I. (1997) Tyrosine 140 of the gamma-aminobutyric acid transporter GAT-1 plays a critical role in neurotransmitter recognition. J. Biol. Chem. 272,16096-16102. 

HTxR, serotonin receptor CB1R, cannabinoid-1 DAT, dopamine transporter GABA, y-aminobutyric acid Kir3 channels, G protein-coupled inwardly rectifying potassium channels LSD, lysergic acid diethylamide i -OR, H-opioid receptor nAChR, nicotinic acetylcholine receptor NET, norepinephrine transporter NMDAR, N -methyl-D-aspartate receptor SERT, serotonin transporter VMAT, vesicular monoamine transporter indicates data not available. 

Kanner, B.I. (1978). Active transport of y-aminobutyric acid by membrane vesicles isolated from rat brain. Biochemistry 17,1207-1211. 

Cyclodienes appear to act more in the central nervous system than in the peripheral nervous system. One major mode of action is the inhibition of y-aminobutyric acid-regulated Cl ion flux in neurons. Cyclodienes also exert effects on membrane-bound adenosine triphosphatases (ATPases), altering Na, K" ", and Ca " " ion transport. The result is a partial depolarization of neurons rather than repolarization... 

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