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Xenobiotic glucuronidation

Burchell B, Brierley CH, Ranee D. Specificity of human UDP-glucuronosyl-transferases and xenobiotic glucuronidation. Life Sci 1995 57(20) 1819—1831. [Pg.113]

Burchell B, Coughtrie MW. Genetic and environmental factors associated with variation of human xenobiotic glucuronidation and sulfation. Environ Health Perspect 1997 105(suppl 4) 739-747. [Pg.113]

Senafi SB, Clarke DJ, Burchell B. Investigation of the substrate specificity of a cloned expressed human bilirubin UDP-glucuronosyltransferase UDP-sugar specificity and involvement in steroid and xenobiotic glucuronidation. Biochem J 1994 303(pt l) 233-240. [Pg.114]

Xenobiotic glucuronidation occurs abundantly in the liver, the intestinal mucosa, and the kidney. Almost all other organs and tissue possess some glucuronidation... [Pg.221]

Renal metabolism of isoproterenol [171], bumet-anide [163], cimetidine [172] and N-methylnicotina-mide [173] has been reported. Renal metabolites may have different mode of excretion [174], and may be more nephrotoxic than the original substance [175]. Renal glucuronidation may be substantial as in the case of morphine [176]. Xenobiotic glucuronidation can proceed by linkage through an ether or an ester bound. [Pg.38]

Substrate Specificity of a Cloned Expressed Human Bilirubin UDP-Glucuronosyltransferase UDP-Sugar Specificity and Involvement in Steroid and Xenobiotic Glucuronidation. [Pg.409]

Glucuronyl transferases A group of enzymes that catalyze the formation of conjugates between glucuronide and a xenobiotic (usually a phase I metabolite). [Pg.332]

The glucuronidation of bifirubin is discussed in Chapter 32 the reactions whereby xenobiotics are glu-curonidated are essentially similar. UDP-glucuronic acid is the glucuronyl donor, and a variety of glu-curonosyltransferases, present in both the endoplasmic reticulum and cytosol, are the catalysts. Molecules such as 2-acetylaminofluorene (a carcinogen), aniline, benzoic acid, meprobamate (a tranquilizer), phenol, and... [Pg.628]

Boelsterli UA. Xenobiotic acyl glucuronides and acyl CoA thioesters as protein-reactive metabolites with the potential to cause idiosyncratic drug reactions. Curr Drug Metab 2002 3(4) 439-450. [Pg.165]

The other primary Phase II metabolic pathway is glucuronidation, which involves the formation ofglucuronic acid conjugates of xenobiotics. This is catalyzed by a family of UDP-glucuronosyl transferases (UGTs) in the presence of uridine diphosphate... [Pg.49]

See other pages where Xenobiotic glucuronidation is mentioned: [Pg.63]    [Pg.190]    [Pg.63]    [Pg.163]    [Pg.63]    [Pg.190]    [Pg.63]    [Pg.163]    [Pg.26]    [Pg.43]    [Pg.48]    [Pg.163]    [Pg.53]    [Pg.211]    [Pg.235]    [Pg.295]    [Pg.1238]    [Pg.142]    [Pg.101]    [Pg.339]    [Pg.148]    [Pg.296]    [Pg.296]    [Pg.123]    [Pg.569]    [Pg.136]    [Pg.152]    [Pg.681]    [Pg.683]    [Pg.155]    [Pg.13]    [Pg.165]    [Pg.176]    [Pg.365]    [Pg.122]    [Pg.452]    [Pg.23]    [Pg.1238]    [Pg.56]    [Pg.39]    [Pg.24]   
See also in sourсe #XX -- [ Pg.63 ]



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Glucuronidated

Glucuronidation

Glucuronidation of xenobiotics

Glucuronides

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