Wyman, Jeffries

In 1965, Jacques Monod, Jeffries Wyman, and Jean-Pierre Changeux proposed a theoretical model of allosteric transitions based on the observation that allosteric proteins are oligomers. They suggested that allosteric proteins can exist in (at least) two conformational states, designated R, signifying relaxed, and T, or taut, and that, in each protein molecule, all of the subunits have the same conformation (either R or T). That is, molecular symmetry is conserved. Molecules of mixed conformation (having subunits of both R and T states) are not allowed by this model. 

Linked Functions and Reciprocal Effects in Hemoglobin A Second Look Jeffries Wyman, Jr. 

The first model was proposed by Jacques Monod, Jeffries Wyman, and Jean-Pierre Changeux in 1965, and is called the MWC model or the concerted model... 

The concerted model was first proposed by Jacques Monod, Jeffries Wyman, and Jean-Pierre Changeux hence, it is often referred to as the MWC model. This model can be formulated in quantitative terms. Consider an enzyme with n identical active sites. Suppose that the enzyme exists in equilibrium between a T form with a low affinity for its substrate and an R form with a high affinity for the substrate. We can define L as the equilibrium constant between the R and the T forms c as the ratio of the affinities of the two forms for the substrate, S, measured as dissociation constants and a as the ratio of substrate concentration to the dissociation constant K... 

The term biophysical chemistry was brought to prominence by the work of John T. Edsall (1902-2002), who died just prior to his 100th birthday. Together with Jeffries Wyman, he wrote the original classic text Biophysical Chemistry, Volume I (Academic Press, 1958), but there never was a Volume 2. This book is dedicated to him and to the many other physical scientists who have dared to enter biological territory. 

Savio L. C. Woo 18 Harland G. Wood 18 W. A. Wood 1, 9 Barbara E. Wright 19 Ray Wu 13 Jeffries Wyman 6 James B. Wyngaarden 5 Gad Yagil 9 Satoshi Yamashita 8 J. Zapf 19 Hans P. Zenner 10 W. Zillig 12... 

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