Wound dressing tissue adhesives

Transparent hydrogels useful for adhesion inhibitors, tissue adhesives, wound dressings, hemostatics and embolisation materials are obtained from dextran methacrylates via polymerisation with N-isopropylacrylamide in DMSO in the presence of azobisisobutyronitrile [176]. A broad variety of new hydrogels with different sensitivities and tunable degradation behaviour is accessible by grafting L-lactide onto 2-hydroxyethyl methacrylate (HEMA) and binding this polymerisable group on dextran via activation with N,N -carbonyldiimidazole (CDI, Sect. 4.2.2) [177]. 

Another important example of the diflFerential adhesiveness which protein-dominated surfaces can display, is in the development of artificial skin especially for wound dressings and for temporary covers of extensive burns. C. W. Hall and co-workers 17) showed that relative tissue adhesion to mechanically identical velour fabrics constructed of various materials follows the order predicted by the critical surface tensions of construction material. 

Wound-dressing materials and tissue engineering are important domains under development [194-200]. New adhesives were proposed recently [201,202], Especially Az-chitosan was shown to be nontoxic, cytocompatible and mechanically suitable in peripheral surgeries [202], Chitosan is suitable for transmucosomal administration of drugs [203],... 

The conclusion to be drawn is that nanocellulose, with its characteristics— nanofibers size and distribution, mechanical properties, compatibility, and ability to regenerate—, has been considered an indispensable biomaterial in health area. Also, the nanocellulose composite scaffolds are biocompatible, appearing as a promising biomaterial, suitable for cell adhesion/attachment, which recommends them for wound-dressing or tissue engineering scaffolds (Kalia et al. 2011). 

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