Wound/dressing interface

Maintain a high humidity at wound/dressing interface... 

P. Connolly, D. McColl, S. Adams, et al, Monitoring Moisture Retention at the Wound-Dressing Interface, Journal of Wound Ostomy Continence Nursing, vol. 31, no. 3S, S26-S27, 2004. 

Bishop, S., Walker, M., Rogers, A., Chen, W. Y. (2003). Importance of moisture balance at the wound dressing interface. Journal of Wound Care, 72(4), 125—128. 

Aspects of the interactionsof the dressing materials to the biological environment were examined next. The interactions studied included changes in the wound at the wound-dressing interface, toxicity of materials on cells, and the effects of degrading materials on tissues. 

A major advantage of these in vitro models is that the test substance can be applied directly (topically) to the culture surface (stratum comeum) at the air interface, thereby closely mimicking dermal exposure in humans. The models are therefore particularly appropriate for irritancy testing of products intended for topical exposure in humans such as treatments for skin conditions, cosmetics, wound dressings, transdermal delivery systems... 

Lately, specific medical treatments that avail themselves of biological or synthetic materials have been applied to support and improve wound healing. These materials may act as passive, interactive, or bioactive dressings. Passive materials include gauzes, tulles, or other traditional products aimed at wound protection, maintenance of suitable moisture, and prevention of microbial infections (Livshits, 1988 Cornelius et al., 2007 Takeoka and Saitoh, 2012). Interactive dressings are mainly biostable polymeric films or foams that can improve gas exchange and permeability at the wound interface. Bioactive dressings have the ability to deliver active biomolecules to the lesion site (Paul and Sharma, 2004). 

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