Ethylamine, reaction with

The starting material was produced by the reaction of furfural with ethylamine followed by hydrogenation to give N-ethyl-N-(2-tetrahydrofurfuryl)amine. Treatment of that material with hydrogen bromide in acetic acid gives N-ethyl-3i3iperidinol. 

Show the products you would obtain by acid-catalyzed reaction of cyclohexanone with ethylamine, CH3CH2NH2, and with diethylamine, (CHjCkD NH. 

The stereochemistry of the addition of amines to acetylenic sulfones has been investigated by Truce and coworkers74. Reaction of phenyl 1-propynyl sulfone with ethylamine gives a mixture of ( )- and (Z)-isomeric adducts (equation 90)75. 

The reactions of [M(CNMe)6]2+ (M = Ru, Os) with amines have been studied. Compound 27 reacts with ethylamine to afford the carbene... 

An extensively studied and highly important 1,2,3-dithiazole - 4,5-dichloro-l,2, 3-dithiazol-l-ium chloride (Appel salt) 145 (R = Cl) - was first prepared by Appel and coworkers in 1985 by chlorination of chloroacetonitiile by sulfur monochloride in dichloromethane (1985CB1632) and it has been the most convenient procedure to date. Appel salt can be obtained also by prolonged chlorination of acetonitrile itself, or by the sulfur monochloride reaction with ethylamine the yields and experimental conditions were not disclosed (1985PS277). Recently, a series of mono-substituted acetonitriles were converted to 5-substituted-4-chloro-l,2,3-dithiazolium chlorides 145 (1999CC531,... 

The direct synthesis of the fused ring compound (55) from the reaction of phosphorus trichloride with ethylamine hydrochloride has already been described (Scheme 16). Its N-methyl analogue (67) can be obtained from the reaction of (MeNPX)3 (X = Cl or Br) with heptamethyldisilazane (Scheme 19). The identification of the structures of these fused-ring compounds, which are structurally related to the bicyclo(3.3.1)nonane carbocycles, pose difficult problems. An example of their... 

Solid cyclic carboxylic anhydrides react with gaseous ammonia to give amide ammonium salts with quantitative yield. This has been observed with the labile Diels-Alder adduct 259 [25] (Scheme 38). Aliphatic amine vapors are equally able to open anhydride rings to form the amide salts from where the free amide acids can be obtained in 100% yield. The reaction of 261 with ethylamine to give 262 is an example of a large-scale preparative application [11-12]. Conversely, solid pyromellitic bis-anhydride (263) and methylamine vapor react exother-mally (rise to 95 °C) and quantitatively to yield the tetraamide 264. Interest-... 

The extensively studied Appel s salt can be produced by prolonged chlorination of acetonitrile with S2CI2 (Scheme 24) <85CB1632>. For preparative purposes chloroacetonitrile gives the best yield (85%). Another simple method for synthesis of Appel s salt may be provided by reaction of S2CI2 with ethylamine (yield and conditions of the process not disclosed) <85PS(23)277>. 

Heteropolyacids Hi4[NaPsW29MoOno] and H3PMO12O4 have been shown to be efficient catalysts for consecutive condensation of aldehydes with 5-aminopyrazole -carboxamide and cyclization into pyrazolo[3,4-t4pyrimidines <2007MI1467>. The reaction of ethyl 5-acylaminopyrazoles with hexachloroethane and triphenylphosphine in the presence of a base has been recently reported to afford an imidoyl chloride that reacted in situ with ethylamine yielding an amidine in 71% yield that cyclized readily in DMF in the presence of potassium carbonate to yield pyrazolopyrimidines in 65% yield <2007TL3983>. 

Probl0m 7.51 Potassium /er/-butoxide, K OCMCj, is used as a base in E2 reactions, (a) How does it compare in effectiveness with ethylamine, CHjCH NH (f>) Compare its effectiveness in the solvents fert-butyl alcohol and dimethylsulfoxide (DMSO) (c) Give the major alkene product when it reacts with (CH JjCClCHjCH,. 

Coburn and Bhoosan reported the first synthesis of 1,3-disubstituted l,3,5-triazine-4,6-dione (82) and the corresponding thione derivative. The dione (82) is thermally stable, but forms ring-opened products on exposure to moisture. The reaction of (82) with dimethyl acetylenedicarboxylate gives the 1 1 adduct rather than the expected cycloaddition products (Scheme 50) (75JHC187). The fused system (83) reacts with ethylamine to produce the 1,3,5-triazine (84 equation 41) (81JCS(Pl)33l). 

This synthetic procedure, using the hydrochloride salt of the amine and sodium cyanoborohydride in methanol, seems to be quite general for ketone compounds related to 3,4-methylenedioxyphenylacetone. Not only were most of the MD-group of compounds discussed here made in this manner, but the use of phenylacetone (phenyl-2-propanone, P-2-P) itself appears to be equally effective. The reaction of butylamine hydrochloride in methanol, with phenyl-2-propanone and sodium cyanoborohydride at pH of 6, after distillation at 70-75 °C at 0.3 mm/ Hg, producedN-butylamphetamine hydrochloride (23.4 g from 16.3 g P-2-P). And, in the same manner with ethylamine hydrochloride there was produced N-ethyl-amphetamine (22.4 g from 22.1 g P-2-P) and with methy lamine hydrochloride there was produced N-methylamphetamine hydrochloride (24.6 g from 26.8 g P-2-P). The reaction with simple ammonia (as ammonium acetate) gives consistently poor yields in these reactions. 

As part of a programme designed to produce compounds with axial chirality, double Bischler-Napieralski reactions were carried out with oxamide derivatives of co-arylalkylamines. Thus, treatment of the oxamide derived from 3,4-dimethoxy- P -pheny lethylamine with pyrophosphoryl chloride in acetonitrile gave 1 in 84% yield, as expected. An attempt was then made to extend this double cyclisation protocol to the oxamide derived from 2-(3-methoxyphenoxy)ethylamine. Reaction of this latter compound under the same conditions used for the formation of 1, however, gave 2 in 81% yield instead of the expected product of a double Bischler-Napieralski reaction. 

Kirmse and coworkers have studied the reaction of alkanediazonium ions with amines and with lithium azide Cyclopropanediazonium ions give azo coupling products 6 and 7 with dimethylamine and with ethylamine, respectively (1) K However, no azo coupling of 1 with phenols was observed. In the reaction... 

Pyrimido[4,5-inorganic bases. Reaction of the pyrimidopyrimidine (125) with ethylamine or methylamine in a sealed tube at 100 °C gives the ring cleaved product (126) (74JCS(P1)1812). 4-Methylthiopyrimido[4,5-with sodium carbonate at 20 °C to give the pyrimidine (128) (60JA6058). 

When the hardening reaction involves cationic polymerization induced by a Lewis acid, however, the functionality of each epoxy group is 2 and that of structure 1-20 is 4. The general hardening reaction is illustrated in Eq. (1-10) for initiation by BF3, which is normally used in this context as a complex with ethylamine, for easier handling. 

The kinetics of the addition of ketene dimer to aromatio amines havo been mvostigated. The dimers of the higher alkylketenes do not react with secondary amines or with phmiyUiydraiine, but their quantitative reaction with ethylamine hae been used for their determination, 2,3-J)ihydro-A, A diiii thyl-p-tketene dimer to form 7.8-dihydio-2,6 dimethy1-chromone. 

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