2- ethylamine reaction with ethyl chloroformate

Ethyl a-acetyl-j3-(2,3-dimethoxy-phenyl)acrylate, 31, 56, 58 Ethyl a-acetyl-/S-(3,4-dimethoxy-phenyl)acrylate, 31, 58 ETHYL a-ACETYL-/3-(2,3-DIMETH0XY-phenyl)propionate, 31, 56 Ethyl a-acetyl-j3-(3,4-dimethoxy-phenyl)propionate, 31, 58 Ethylamine, reaction with chloroform, 35, 64... 

Two classical methods based on methylamines 58a have been developed for preparation of substituted methyl isocyanides-the second component of the reaction shown in Scheme 4.28. The first method consists of one stage, namely, treatment of amines with chloroform in the presence of alkalis the second method consists of two stages. The reaction with ethyl formate leads to formamides 58b, which are then dehydrated by treating with phosphorus oxochloride in the presence of tri-ethylamine (Scheme 4.29) (Jacobsen et al. 1996a). 

V- 6-[2-(7-methyl[l, 8]naphthyridin-2-yl)ethyl]pyridine-2-yl acetamide 356 was prepared by the reaction of 2,7-dimethyl-l,8-naphthyridines 357 with n-butyllithi-um and 2-/V-acetylamino-6-bromomethylpyridine 358. Another carrier, viz., N-(l-methyl[l,8]naphthyridin-2-yl)-7V -(6-methylpyridin-2-yl)isophtalamide 359, was synthesized from 2-amino-7-methyl-l,8-naphthyridine 360, 2-amino-6-methylpyridine 226a and isophthaloyl chloride 361 in dry dichloromethane in the presence of tri-ethylamine. N,N -bis(l-mcl y [, 8]naphthyridin-2-yl)isophthalamide 362 was prepared from naphthyridines 360 and chloride 361 under analogous conditions. Isophthalamides 359 and 362 were used for the determination of L-( + )tartaric acid as complexes (1 1) soluble in chloroform (1999JIC661, 2001T4987). 

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