Weighted dose index

The HI Approach For historical reasons seemingly based on data availability, the HI approach is the most often used approach, and it is traditionally applied to noncarcinogens. The hazard index is found by integratings the exposure level and the related toxicity into a single value with potency-weighted dose additions. The HI approach is simple to implement but somewhat limited in its scope, however, since it can underpredict or overpredict risk estimates. Initially... 

Water extract of the dried seed at a concentration of 2 mg/mL was active on macrophages. Nitrate formation was used as an index of the macrophage stimulating activity to screen effective foods """. Weight-gain inhibition. Seed oil administered subcutaneously to mice at a dose of 0.05 mL/animal was active. Brain weight also decreased after 210 days of dosing " . 

Table II shows the effect of various doses of electron irradiation on the solubility of ethylene-ethylacrylate copolymer. Extraction with boiling toluene for 64 hours revealed extensive crosslinking after absorption of a 5-megarep dose of radiation. Copolymers of ethylene with isobutyl acrylate and 2-ethylhexyl acrylate were examined briefly. A 29 wt.% isobutyl acrylate-ethylene copolymer of melt index 1.3 decigrams per minute was crosslinked to greater than 50% insolubility in boiling toluene by a radiation dose of 10 megareps. A copolymer containing 21% by weight of 2-ethylhexyl acrylate of melt index 8 decigrams per minute required a dose of 25 megareps to reach a 50% level of insolubility.

Sprague-Dawley rats and Swiss CD-I mice were exposed by inhalation to 0, 280, 1400 or 7000 ppm [800-19 530 mg/m ] isoprene for 6 h per day on seven days per week on gestational days 6-19 (rats) or 6-17 (mice) (lARC, 1994). There was no adverse effect on rat dams or other reproductive index at any dose level. The only fetal malformation observed in rats was reduced ossification of the vertebral centra, which occurred at 7000 ppm isoprene. In mice, there was reduced fetal body weight at all dose levels and decreased maternal weight gain in the 7000-ppm group. Also in the 7000-ppm group, there was an increased incidence of supernumerary ribs but no increase in fetal malformations. 

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