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Water-soluble taxol prodrugs

A Water-soluble taxol prodrugs 572 B Existence of mixed-type prodrugs 580... [Pg.561]

Ueda, Y., et al. 1993. Novel water soluble phosphate prodrugs of taxol(R) possessing in vivo antitumor activity. Bioorg Med Chem Lett 3 1761. [Pg.129]

Greenwald, R. B. Rendri, A. Bolikal, D. Gilbert, C. W. Highly water soluble taxol derivatives 2 -polyethyleneglycol esters as potential prodrugs. Bioorg. Med. Chem. Lett., 1994, 4 2465-2470. [Pg.138]

Greenwald, R.B., et al.. Drug delivery systems water soluble taxol 2 -poly(ethylene glycol) ester prodrugs-design and in vivo effectiveness. Journal of Medical Chemistry, 1996, 39, 424-A31. [Pg.229]

Greenwald RB, Gilbert CW, Pendri A, Conover CD, Xia J, Martinez A (1996) Drug Delivery Systems Water Soluble Taxol 2 -Poly(ethylene glycol) Ester Prodrugs -Design and in Vivo Effectiveness. J Med Chem 39 424... [Pg.214]

Greenwald, R., Gilbert, C. W., and Pendri, A. 1996. Drug delivery systems Water soluble taxol 2 -poly(ethylene glycol) ester prodrug-design and in vitro effectiveness. J. Med. Chem. 39 424 31. [Pg.336]

Mathew, A. E., M. R. Mejillano, J. P. Nath, R. H. Himes, andV. J. Stella. 1992. Synthesis and evaluation of some water-soluble prodrugs and derivatives of taxol with antitumor actiilitjdled. Chem35 145-151. [Pg.464]

Zhao, Z., D. G. I. Kingston, andA. R. Crosswell. 1991. Moddtaxols. 6. Preparation of water soluble prodrugs of taxol. J. Nat. Prod.54 1607-1611. [Pg.466]

Taxol (paclitaxel) is a cytotoxic drug that has been shown to have potent antileukemic and tumor inhibitory properties. Taxol suffers from very poor water solubility (0.25 pg/mL), and hence, a few phosphate ester prodrugs of taxol have been synthesized. While great improvement of water solubility was achieved (>10 mg/mL), these prodrugs were resistant to degradation by alkaline phosphatase, probably due to hindered enzyme access, and no free taxol was formed [50],... [Pg.120]

Nicolaou, K. C., Guy, R. K., Pitsinos, E. N., Wrasidlo, W. A water-soluble prodrug of taxol with self-assembling properties. Angew. Chem. Int. Ed. 1994. (in press)... [Pg.745]

Recent studies on taxol related water-soluble prodrugs 01MI122. [Pg.28]

These analogs had improved water-solubility and comparable Ml09 in vivo activity to taxol, and were thus stated to be suitable prodrugs of taxol the carbonate 10.2.8 was especially promising in this regard (363), and a radioactive derivative of it was prepared (364). [Pg.140]

The concept of linking taxol to a water-soluble polymer to improve its solubility and possibly also its pharmacokinetics has been investigated by several groups. Thus Greenwald et al. prepared 2 -(polyethyl-eneglycol) esters of taxol as potential prodrugs (366, 367), and similar compounds were also prepared by Li and his colleagues (368). The 2 -... [Pg.140]

Mathew AE, Mejillano MR, Nath JP, Himes RH, Stella VJ (1992) Synthesis and Evaluation of Some Water-Soluble Prodrugs and Derivatives of Taxol with Antitumor Activity. J Med Chem 35 145... [Pg.201]

Deutsch HM, Glinski JA, Hernandez M, Haugwitz RD, Narayanan VL, Suffness M, Zalkow LH (1989) Synthesis of Congeners and Prodrugs. 3. Water-Soluble Prodrugs of Taxol with Potent Antitumor Activity. J Med Chem 32 788... [Pg.213]

Zhao Z, Kingston DGI, Crosswell AR (1991) Modified taxols, 6. Preparation of Water-Soluble Prodrugs of Taxol. J Nat Prod 54 1607... [Pg.213]

Kingston DGI, Liang J (1995) Water Soluble Analogs and Prodrugs of Taxol. U.S. Patent 5,411,984... [Pg.213]


See other pages where Water-soluble taxol prodrugs is mentioned: [Pg.731]    [Pg.572]    [Pg.731]    [Pg.558]    [Pg.731]    [Pg.572]    [Pg.731]    [Pg.558]    [Pg.462]    [Pg.214]    [Pg.571]    [Pg.95]    [Pg.118]    [Pg.233]    [Pg.138]    [Pg.192]    [Pg.139]    [Pg.551]    [Pg.558]    [Pg.558]    [Pg.172]    [Pg.453]   
See also in sourсe #XX -- [ Pg.732 ]

See also in sourсe #XX -- [ Pg.732 ]




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Prodrug

Prodrugs soluble

Solubility prodrugs

Taxol

Taxols

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