Water platinum complex

Loss of Cl makes the platinum complex more reactive, since water is better leaving group than Cl-. 

The platinum complex (NH3)2PtCl2 is a well-known antitumor agent. Because the drug is soluble in water, it is readily excreted through the kidneys and can cause severe kidney damage. Various procedures are employed clinically to minimize these side effects, but the... 

The stereoselective catalyzed addition of water or methanol to dimethyl acetylenedicarboxylate (DMAD) was reported to yield oxalacetic acid dimethylester or dimethyl methoxyfumarate. The catalyst precursor cis-[Pd(PMe2Ph)2(solvent)2] [BFJj was prepared from ds-[PdCl2(PMe2Ph)2] and AgBp4 (Eq. 6.54). The analogous platinum complex was not effective, however [99]. 

More recently, Atwood et al. developed a platinum complex of a water-soluble, bidentate phosphine ligand, cA-(TPPTS)2PtCl2 [TPPTS = tris(sodium m -benzenesuI onatc)phosphi nc, as an effective hydration... 

Since it is known that the tetranuclear mixed-valent platinum-blue complexes such as 19 and 57 undergo disproportionation and reduction by water as Eqs. (1)—(3) and (7)—(9) show (106, 113), all the species appearing in Eqs. (1)—(3) and (7)—(9) are present in the solution. However, only one or several of the four species in the solution may in fact be resposible for the catalytic olefin oxidation. To clarify this point, the effect of the Pt oxidation state in the platinum complexes was compared. The results are summarized in Table VII, which... 

Crystals of Rb, 6 [Pt(CN)4] 2H20 lose water easily and must be stored over a saturated solution of NH4C1 and KN03, which has a relative humidity of 72% at 23° (H20 vapor pressure 15.15 torr).8 The compound may be recrystallized from water. This platinum complex has a density of 3.31 g/cm3. 

Since these substitution reactions follow a two-term rate law, it is clear that solvent effects are very significant. Poorly coordinating solvents are benzene, carbon tetrachloride and sterically hindered alcohols and strongly coordinating solvents are water, lower alcohols, DMF, DMSO, acetonitrile and nitromethane. The first-order rate constants are greater in DMSO than in water. Since the majority of precursor platinum complexes used in synthetic and mechanistic studies are halo complexes, the replacement of halide ligands by solvent and the reversibility of this reaction are important features of platinum halide chemistry. 

Attempts have been made to mimic proposed steps in catalysis at a platinum metal surface using well-characterized binuclear platinum complexes. A series of such complexes, stabilized by bridging bis(diphenyl-phosphino)methane ligands, has been prepared and structurally characterized. Included are diplati-num(I) complexes with Pt-Pt bonds, complexes with bridging hydride, carbonyl or methylene groups, and binuclear methylplatinum complexes. Reactions of these complexes have been studied and new binuclear oxidative addition and reductive elimination reactions, and a new catalyst for the water gas shift reaction have been discovered. 

In modem chemotherapy platinum complex compounds are some of the most efficient anticancer drugs. Platidiam is manufactured in a lyophilizate form in vials, the components ratio is 10 mg of cfr-platinum, 100 mg of manitol, and 90 mg of sodium chloride. It is a yellow powder soluble in water, physiological solutions, and dimethylformamide.10... 

Although the visible and ultraviolet spectra of the platinum metal complexes serve as a valuable means to follow their reactions, this feature is especially disturbing to one who is trying to establish the energy states for a particular species. Some care is necessary to establish that the measured spectrum results from the particular complex species of interest, and not some of its reaction products. Water is an effective nucleophile for these complexes. To avoid solvation of some platinum complexes, Mason and Gray (21) have recently reported spectra of the tetrabutyl-... 

There have been several recent studies of homogeneous catalysis of the water gas shift reaction (equation 7) by mononuclear and cluster catalysts, including mononuclear platinum complexes (15). 

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