Warfarin characterized

Hildebrand EF, Preusch PC, Patterson JL, and Suttie JW (1984) Solubilization and characterization of vitamin K epoxide reductase from normal and warfarin-resistant rat liver microsomes. Archives of Biochemistry and Biophysics 228,480-92. 

K. J. Fehske, U. Schlafer, U. WoUert, and W. E. Muller, Characterization of an important drug binding area on human serum albumin, including the high-affinity binding sites of warfarin and azapropazone. Mo/. Pharmacd., 21 387 (1982). 

Loun, B. Hage, D.S. Characterization of thyroxine-albumin binding using high-performance affinity chromatography. I. Interactions at the warfarin and indole sites of albumin. J. Chromatogr. 1992, 579, 225-235. 

Zhang N, Seguin RP, Kunze KL, Zhang YY, Jeong H (2013) Characterization of inhibition kinetics of (S)-watfarin hydtoxylation by noscapine implications in warfarin therapy. Drug Metab Dispos 41 2114-2123... 

Calciphylaxis, a rare, usually fatal disorder characterized by cutaneous ischemia and necrosis due to calcification of arterioles, has been described in a 63-year-old Polynesian woman who was taking warfarin [3 ]. Enoxaparin was used instead and after 40 sessions of hyperbaric oxygen therapy her leg ulcers resolved. The authors attributed the calciphylaxis in this case to warfarin. 

In Chapter 10, Method Development, in the first edition of the Handbook of Modern Pharmaceutical Analysis, the basics for pharmaceutical chromatographic separations were discussed. These separations are called achiral chromatography for the separations are not stereospecific. In today s pharmaceutical industry, our separation needs do not end simply in the achiral realm. The active pharmaceutical ingredients (APIs) are not only resolved from impurities and degradants but are also required by compendial guidelines to be characterized in terms of its enantiomeric purity. For example, warfarin, a common anticoagulant, can be synthesized in two enantiomeric forms R-(+) and S-(—) (Figure 1). 

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