Walker, Steve

The authors wish to acknowledge the critical review of the manuscript by Drs. Melissa Jacob and Larry Walker and would also like to acknowledge other members of the NCNPR natural products community including Steve Duke, Aruna Weerasooriya, Maria Bennett, Mary Heather Martin, Derek Oglesby, and Ed Lowe. This research is funded in part by the U.S. Department of Agriculture s Agricultural Research Service Specific Cooperative Agreement 58-6408-2-0009. 

Walker, C. H., Steve P. Hopkin, R. M. Sibly, and D. B. Peakall, Principles of Ecotoxicology, 3rd ed., Taylor Francis/CRC Press, Boca Raton, FL, 2005. 

Other experiments with herpesviruses have lent only limited support to the theory that ionic imbalance causes selective shut-off of cellular protein synthesis after infection. A differential sensitivity to hypertonic medium has been reported in cells infected with human or murine cytomegaloviruses which cause only a very slow decline late in infection (Gupta and Rapp, 1978 Chantler, 1978), but in HSV-2-infected cells (Fenwick and Walker, 1978) and PRV-infected cells (Stevely and McGrath, 1978) viral protein synthesis was as susceptible as protein synthesis in uninfected cells to increased concentrations of NaCl. No differences have been found between the concentrations of ions needed for optimal translation in vitro of viral (HSV-1 or PRV) and cellular mRNAs, respectively (Inglis and Newton, 1981 McGrath and Stevely, 1980). Attempts to prevent the early shut-off of protein synthesis by HSV-2 by reducing the Na or Ca concentration in the medium were not successful (Fenwick and Walker, 1978), but these experiments were done at times which probably preceded the permeability changes described by Benedetto et al. (1980). 

Steven Gutteridge, Steve O. Pember, LiHong Wu, Yong Tao, and Mike Walker ... 

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