W-Acetylcystein

W. Droge and R. Breitkreutz, N-Acetylcysteine in the Therapy on HIV-Positive Patients, Curr Opin Clin Nutr Met Care 2 (1999) 493-498. 

Tepel M, Zidek W. Acetylcysteine and contrast media nephropathy. Curr Opin Nephrol Hypertens 2002 I 1 503-506. 

Wegener, T., B. Sandhagen, K.W. Chan, and T. Saldeen. 1988. V-acetylcysteine in paraquat toxicity toxicological and histological evaluation in rats. Uppsala Jour. Med. Sci. 93 81-89. 

W.T. Suarez, H.J. Vieira, O. Fatibello-Filho, Flow injection turbidimetric determination of acetylcysteine in pharmaceutical formulations using silver nitrate as precipitant reagent, J. Braz. Chem. Soc. 18 (2007) 1028. 

Smilkstein MJ, Knapp GL, Kulig KW, Rumack BH. Efficacy of oral W-acetylcysteine in the treatment of acetaminophen overdose Analysis of the national multicenter study (1976-1985). N Engl J Med 1988 319 1557-1562. 

Banner W, Koch M, Capin M, et al. 1986. Experimental chelation therapy in chromium, lead, and boron intoxication with V-acetylcysteine and other compounds. Toxicol Appl Pharmacol 83 142-147. 

Lund M, Banner W, Clarkson T, Berlin M. 1984. Treatment of acute methylmercury ingestion by hemodialysis with n-acetylcysteine (Mucomyst) infusion and 2,3-dimercaptopropane sulfonate. J Toxicol Clin Toxicol 22(l) 31-49. 

CHIAO J W, CHUNG F, KRZEMINSKI J, AMIN S, ARSHAD R, AHMED, T aud CONAWAY C C (2000) Modulation of growth of human prostate cancer cells hy the N- acetylcysteine conjugate of pheuethyl isothiocyanate , Int J Oncol, 16 1215-9. 

Acetaminophen N, V, Pallor, tachycardia, RUQ pain Symptomatic/supportive / acetylcysteine (Acetadote) w/in 8 h 

Tepel M, van der Giet M, Schwarzfeld C, Laufer U, Liermann D, Zidek W Prevention of radiographic-contrast-agent-induced reductions in renal function by acetylcysteine. N Engl J Med 343 180-4,2000 

Szasz, G., Gruber, W., and Bernt, E., Creatine kinase in serum. I. Determination of optimum reaction conditions, Clin. Chem. 22, 650-656, 1976 Holdiness, M.R., Clinical pharmacokinetics of W-acetylcysteine, Clin. Pharmacokinet. 20, 123-134, 1991 Kelley, G.S., Clinical applications of W-acetylcysteine, Altem. Med. Rev. 3, 114-127, 1998 Schumann, G., Bonora, R., Ceriotti, F. et ah, IFCC primary reference procedures for the measurement of catalytic activity concentrations of enzymes at 37°C. Part 2. Reference procedure for the measurement of catalytic concentration of creatine kinase, Clin. Chem. Lab. Med. 40, 635-642, 2002 Zafarullah, M., Li, W.Q., Sylvester, J., and Ahmad, M., Molecular mechanisms of A -acetylcysteine actions. Cell. Mol. Life Sci. 60, 6-20, 2003 Marzullo, L., An update of A-acetylcysteine treatment for acute aminoacetophen toxicity in children, Curr. Opin. Pediatr. 17, 239-245, 2005 Aitio, M.L., A-acetylcysteine — passepartout or much ado about nothing Br. J. Clin. Pharmacol. 61, 5-15, 2006. 

F. Taut, C. Zapletal, E. Klar, J. Motsch, J. Thies, A. Babylon, E. Martin, W. Droge and R. Breitkreutz, Sulfur-Containing Metabolites on N-Acetylcysteine in Patients Undergoing Orthotopic Liver Transplantation, Transplant Proc 31 (1999) 411-413. 

TSAI J-C, JAIN M, HSIEH C-M, LEE W-S, YOSHIZUMI M, PATTERSON C, PERRELLA M A, COOKE C, WANG H, HABER E, scHLEGEL R, and LEE M E (1996) Induction of apoptosis by pyrrolidinedithiocarbamate and N-acetylcysteine in vascular smooth muscle cells Journal Biological Chemistry 271, 3667-70. 

The rates depend on the thiol structure, and correlate well with inductive effects. Thus, the -NH2 and COO groups destabilize and stabilize the red adduct, respectively. When the groups are blocked by acetylation or esterification, their influence is suppressed, as shown by W-acetylcysteine, which forms the most stable adduct in the series because of the unprotected COO and the acetylated amino group. 

Kastrup J, Petersen P, Bertram R, Flansen JM.The effect of trimethoprim on serum creatinine. Brit J Urol 1985 57 265-268. Floffmann U, Fischereder M, Kruger B, Drobnik W, Kramer BK. The value of N-acetylcysteine in the prevention of radiocontrast agent-induced nephropathy seems questionable. J Am Soc Nephrol 2004 15 407 -410. 

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