W-Acetylcystein

Tepel M, Zidek W. Acetylcysteine and contrast media nephropathy. Curr Opin Nephrol Hypertens 2002 I 1 503-506. 

Szasz, G., Gruber, W., and Bernt, E., Creatine kinase in serum. I. Determination of optimum reaction conditions, Clin. Chem. 22, 650-656, 1976 Holdiness, M.R., Clinical pharmacokinetics of W-acetylcysteine, Clin. Pharmacokinet. 20, 123-134, 1991 Kelley, G.S., Clinical applications of W-acetylcysteine, Altem. Med. Rev. 3, 114-127, 1998 Schumann, G., Bonora, R., Ceriotti, F. et ah, IFCC primary reference procedures for the measurement of catalytic activity concentrations of enzymes at 37°C. Part 2. Reference procedure for the measurement of catalytic concentration of creatine kinase, Clin. Chem. Lab. Med. 40, 635-642, 2002 Zafarullah, M., Li, W.Q., Sylvester, J., and Ahmad, M., Molecular mechanisms of A -acetylcysteine actions. Cell. Mol. Life Sci. 60, 6-20, 2003 Marzullo, L., An update of A-acetylcysteine treatment for acute aminoacetophen toxicity in children, Curr. Opin. Pediatr. 17, 239-245, 2005 Aitio, M.L., A-acetylcysteine — passepartout or much ado about nothing Br. J. Clin. Pharmacol. 61, 5-15, 2006. 

Smilkstein MJ, Knapp GL, Kulig KW, Rumack BH. Efficacy of oral W-acetylcysteine in the treatment of acetaminophen overdose Analysis of the national multicenter study (1976-1985). N Engl J Med 1988 319 1557-1562. 

The rates depend on the thiol structure, and correlate well with inductive effects. Thus, the -NH2 and COO groups destabilize and stabilize the red adduct, respectively. When the groups are blocked by acetylation or esterification, their influence is suppressed, as shown by W-acetylcysteine, which forms the most stable adduct in the series because of the unprotected COO and the acetylated amino group. 

The hypothesis that the ageing-related increase in the risk of heart disease may be causally related to the ageing-related shift in plasma thiol/disul-phide redox state is supported by several clinical studies on W-acetylcysteine (for review see Droge 2002). 

Izzotti A, Camoirano A, D Agostini F, Sciacca S, De Naro Papa F, Cesarone CF, De Flora S. Biomarker alterations produced in rat lung hy intratracheal instillations of air particulate extracts and chemoprevention with oral W-acetylcysteine. Cancer Res 1996 56 1533-1538. 

TSAI J-C, JAIN M, HSIEH C-M, LEE W-S, YOSHIZUMI M, PATTERSON C, PERRELLA M A, COOKE C, WANG H, HABER E, scHLEGEL R, and LEE M E (1996) Induction of apoptosis by pyrrolidinedithiocarbamate and N-acetylcysteine in vascular smooth muscle cells Journal Biological Chemistry 271, 3667-70. 

CHIAO J W, CHUNG F, KRZEMINSKI J, AMIN S, ARSHAD R, AHMED, T aud CONAWAY C C (2000) Modulation of growth of human prostate cancer cells hy the N- acetylcysteine conjugate of pheuethyl isothiocyanate , Int J Oncol, 16 1215-9. 

Wegener, T., B. Sandhagen, K.W. Chan, and T. Saldeen. 1988. V-acetylcysteine in paraquat toxicity toxicological and histological evaluation in rats. Uppsala Jour. Med. Sci. 93 81-89. 

Acetaminophen N, V, Pallor, tachycardia, RUQ pain Symptomatic/supportive / acetylcysteine (Acetadote) w/in 8 h... 

Tepel M, van der Giet M, Schwarzfeld C, Laufer U, Liermann D, Zidek W. Prevention of radiographic-contrast-agent-induced reductions in renal function by acetylcysteine. N Engl J Med 2000 343 180-184. 

T.W.C. Lo, M.E. Westwood, A.C. McLellan, T. Selwood, and PJ. Thomalley, Binding and modification of proteins by methylglyoxal under physiological conditions a kinetic and mechanistic study with A,K-acelyIargi ni nc, -acetylcysteine, and A -acetyllysine, and bovine serum albumin. J. Biol. Chem., 1994, 269, 32299-32305. 

Banner W, Koch M, Capin M, et al. 1986. Experimental chelation therapy in chromium, lead, and boron intoxication with V-acetylcysteine and other compounds. Toxicol Appl Pharmacol 83 142-147. 

F. Taut, C. Zapletal, E. Klar, J. Motsch, J. Thies, A. Babylon, E. Martin, W. Droge and R. Breitkreutz, Sulfur-Containing Metabolites on N-Acetylcysteine in Patients Undergoing Orthotopic Liver Transplantation, Transplant Proc 31 (1999) 411-413. 

W. Droge and R. Breitkreutz, N-Acetylcysteine in the Therapy on HIV-Positive Patients, Curr Opin Clin Nutr Met Care 2 (1999) 493-498. 

Kastrup J, Petersen P, Bertram R, Flansen JM.The effect of trimethoprim on serum creatinine. Brit J Urol 1985 57 265-268. Floffmann U, Fischereder M, Kruger B, Drobnik W, Kramer BK. The value of N-acetylcysteine in the prevention of radiocontrast agent-induced nephropathy seems questionable. J Am Soc Nephrol 2004 15 407 -410. 

Lund M, Banner W, Clarkson T, Berlin M. 1984. Treatment of acute methylmercury ingestion by hemodialysis with n-acetylcysteine (Mucomyst) infusion and 2,3-dimercaptopropane sulfonate. J Toxicol Clin Toxicol 22(l) 31-49. 

W.T. Suarez, H.J. Vieira, O. Fatibello-Filho, Generation and destruction of unstable reagent in flow injection system determination of acetylcysteine in pharmaceutical formulations using bromine as reagent, J. Pharm. Biomed. Anal 37 (2005) 771. 

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