Vytorin

Metoprolol 1 00 mg by mouth twice daily Hydrochlorothiazide 25 mg by mouth daily Vytorin 10/40 (ezetimibe 10 mg/simvastatin 40 mg) by mouth daily... [Pg.142]

Ezetimibe interferes with the absorption of cholesterol from the brush border of the intestine, a novel mechanism that makes it a good choice for adjunctive therapy. It is approved as both monotherapy and for use with a statin. The dose is 10 mg once daily, given with or without food. When used alone, it results in an approximate 18% reduction in LDL cholesterol. When added to a statin, ezetimibe lowers LDL by about an additional 12% to 20%. A combination product (Vytorin) containing ezetimibe 10 mg and simvastatin 10, 20, 40, or 80 mg is available. Ezetimibe is well tolerated approximately 4% of patients experience GI upset. Because cardiovascular outcomes with ezetimibe have not been evaluated, it should be reserved for patients unable to tolerate statin therapy or those who do not achieve satisfactory lipid lowering with a statin alone. [Pg.120]

Ezetimibe/Simvastatin (Vytorin) [Antilipemic/HMG CoA Reductose Inhibitor] Uses H rp cholest olemia Action X Absorption of cholesterol phytost ol w/ HMG-CoA reductase inhibitor Dose 10/10-10/80 mg/d PO w/ cyclosporine or danazol 10/10 mg/d max w/ amio-darone or verapamil 10/20 mg/d max -1- w/ sev e renal insuff Caution [X, -] w/ CYP3A4 inhibitors (Table VI-8), gemfibrozil, niacin >lg/d, danazol, amiodarone, verapamil Contra PRG/lactation livCT Dz, t LFTs Disp Tabs SE HA, GI upset, myalgia, myopathy (muscle pain, weakness, or tendOTiess w/ CK 10 x ULN, rhab-domyolysis), Hep, Infxn Interactions t Risk of myopathy W7 clarithromycin, erythromycin, itraconazole, ketoconazole EMS None OD Sxs unknown symptomatic and supportive... [Pg.161]

Top 20 brands (figures in billion) Vytorin/Zetia (Merch/Schering-Plough), 2.4 Avandia/ Avandamet (gsk), 2.4 Glivec, 2.2 NeoRecormon, Epogin (Roche), 1.8. [Pg.98]

December 1998 labeling VYTORIN 10/10 (Schering) Warnings (ezetimibe/simvastatin) July 2004 labeling... [Pg.267]

Oral 500/20, 750/20, 1000/20 mg tablets Vytorin (ezetimibe plus simvastatin)... [Pg.794]

It makes Cozaar and Hyzaar for hypertension Vytorin, Zetia, and Zocor to lower cholesterol Pro-pecia for male-pattern baldness Singulair for asthma Fosamax for osteoporosis and Gardasil, a vaccine for cervical cancer but it is also well known for making Vioxx, a pain relief drug taken off the market for causing heart problems. [Pg.211]

Questran, Questran Light, Prevalite) Colesevelam (WelChol) Colestipol (Colestid) Ezetimibe (Zetia) Ezetimibe/Simvastatin (Vytorin)... [Pg.40]

Ezetimibe is a newer dmg that inhibits cholesterol absorption by the G1 tract it reduces LDLc modestly as monotherapy and is used in combination therapy with simvastatin (marketed as Vytorin) to achieve good cholesterol lowering and minimizing... [Pg.1024]

Trade names Vytorin Zetia Indications Hypercholesterolemia Category Cholesterol inhibitor Half-life 22 hours... [Pg.228]

Trade names Denan Lipex Liponorm Lodales Simovil Sivastin Vytorin Zocor (Merck) Zocord Indications Hypercholesterolemia Category HMG-CoA reductase inhibitor Statin Half-life 1.9 hours... [Pg.525]

Simvastatin Vytorin (with ezetlmlbe), Zocor Hypolipaemic 43605... [Pg.897]

Ezetlmlbe Zetla, Vytorin (with simvastatin) Anti-cholesterol 25434... [Pg.897]

Merck also have the combination of atorvastin (60, Figure 11) and ezetimibe (62, Figure 11) in phase II clinical trials, an interesting adjunct to Vytorin. [Pg.639]

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See also in sourсe #XX -- [ Pg.161 ]

See also in sourсe #XX -- [ Pg.171 ]

See also in sourсe #XX -- [ Pg.201 , Pg.204 ]

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