Vomiting octreotide

Octreotide -synthetic peptide analogue of somatostatin -abdominal pain, nausea, vomiting, diarrhea -local injection site reactions -cholelithiasis -sweating, flushing -hyperglycemia (many patients will require insulin therapy)... 

Adverse effect of octreotide include nausea, vomiting, abdominal cramps and steatorrhea. 

Adverse effects of octreotide therapy include nausea, vomiting, abdominal cramps, flatulence, and steatorrhea with bulky bowel movements. Biliary sludge and gallstones may occur after 6 months of use in 20-30% of patients. However, the yearly incidence of symptomatic gallstones is about 1%. Cardiac effects include sinus bradycardia (25%) and conduction disturbances (10%). Pain at the site of injection is common, especially with the long-acting octreotide suspension. Vitamin B12 deficiency may occur with long-term use of octreotide. 

Severe hypertension with associated headache, nausea, and vomiting was reported within 2 weeks of administration of octreotide LAR 20 mg in a 26-year-old diabetic woman with autonomic neuropathy (6). Rechallenge with octreotide 75 pg resulted in a transient hypertensive episode lasting 3 hours. 

Octreotide Nausea and vomiting diarrhoea Steatorrhoea gallstones... 

Octreotide is a long-acting somatostatin analog that inhibits the secretion of serotonin, vasoactive intestinal peptide, gastrin, motilin, insulin, glucagons, secretin, and pancreatic polypeptide. It is used for the control of symptoms in patients with carcinoid and vasoactive intestinal peptide-secreting tumors (VIPomas). Its major toxicity is nausea and vomiting. 

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