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Vitamin Trimers

Figure 1 Examples of several bacterial membrane proteins. The outer membrane (OM) of Gram-negative bacteria contains exclusively fS-barrel proteins, and three examples are shown BtuB (PDB ID 1NQF), which is the 22 p-stranded TonB-dependent active transporter for vitamin B 2/ th LamB or maltoporin trimer (PDB ID 1AF6), which is the 18 p-stranded passive sugar transporter and OmpA (PDB ID 1BXW), which is an 8 p-stranded protein that provides structural support for the OM. Proteins in the cytoplasmic membrane (CM) are helical, and three examples are shown the potassium channel KcsA (PDB ID 1BL8), which is a tetramer Sec YEG (PDB ID 1RH5), which forms the protein transport channel in Methanococcus and BtuCD (PDB ID ... Figure 1 Examples of several bacterial membrane proteins. The outer membrane (OM) of Gram-negative bacteria contains exclusively fS-barrel proteins, and three examples are shown BtuB (PDB ID 1NQF), which is the 22 p-stranded TonB-dependent active transporter for vitamin B 2/ th LamB or maltoporin trimer (PDB ID 1AF6), which is the 18 p-stranded passive sugar transporter and OmpA (PDB ID 1BXW), which is an 8 p-stranded protein that provides structural support for the OM. Proteins in the cytoplasmic membrane (CM) are helical, and three examples are shown the potassium channel KcsA (PDB ID 1BL8), which is a tetramer Sec YEG (PDB ID 1RH5), which forms the protein transport channel in Methanococcus and BtuCD (PDB ID ...
The mode of action of Smad 4 clearly differs from that of the other members of the Smad family. Smad 4 binds to phosphorylated R-Smads and forms trimeric complexes composed of two R-Smad molecules and one Smad 4 molecule. These complexes translocate to the nucleus, where they bind to related DNA elements and activate the transcription of target genes. The mechanism of transcription regulation by Smads is complex and includes both positive and negative influences. Generally, Smad-dependent regulation of transcription requires the interaction with other transcription factors, such as members of the FoxH 1 family of forkhead transcription factors, the Vitamin D receptor and the c-Jun transcription factor, among others (review Attisano et al., 2001). Futhermore, Smads can interact with coactivators and corepressors of transcription and thereby recruit, e. g., histone acetylase activity or histone deacetylase activity to chromatin. [Pg.420]

Selective enzymic acylation and deacylation of nucleosides have been reviewed. Cordycepin (3 -deoxyadenosine) has been linked to various lipophilic vitamins and to diacylglycerols via dicarboxylic acid spacers at 0-2 and 0-5, and similar conjugates have been made to the cordycepin trimer core, with linkages at either the 5 - or the 2 -end. 3 -(9-Aminoacyl-2 -deoxynucleosides have been made using Fmoc aminoacid fluorides as acylating agents. ... [Pg.299]

Studies of the metabolism of vitamin E were triggered by the observations of Alaupovic and coworkers [126, 127]. When " [Cj-D-a-tocopherol-5-methyl was administered to rats or pigs and attempts were made to detect metabolic derivatives, two compounds were separated by chromatography. One of the compounds is " [C]-D-a-tocopherol quinone the other is either a dimer or a trimer of a-tocopherol. The dimer and trimer are terminal oxidation products of a-tocopherol and are excreted in the bile. a-Tocopherol quinone can be converted to a-hydroquinone. a-Tocopherol hydroquinone may be esterified in liver and eliminated in the feces after concentration in the bile and excretion in the intestine, or it may be oxidized in the kidney to a-tocopheronic acid, which may be converted into an a-tocopheronolactone conjugate, which is excreted in the urine. In conclusion, vitamin E is excreted as such in the urine or the bile after conversion to a dimer or a trimer, in the form of a conjugated hydroxy-quinone or tocopheronic acid (see Fig. 4-43). [Pg.315]

The reaction can be extended to the case in which two alkynes and a nitrile are trimerized to give a pyridine or two alkynes and an isocyanate are tri-merized to give an a-pyridone, also shown in Eq. 14.63, as exemplified in syntheses of vitamin 85, a pyridine derivative, and the antitumor agent, camptothecin, an a-pyridone. [Pg.394]

The free radical reaction may be accelerated and propagated via chain branching or homolytical fission of hydroperoxides formed to generate more free radicals (equations (11.4), (11.5)). Free radicals formed can initiate or promote fatty acid oxidation at a faster rate. Thus, once initiated, the free radical reaction is self-sustaining and capable of oxidizing large amounts of lipids. On the other hand, the free radical chain reaction may be terminated by antioxidants (AH) such as vitamin E (tocopherols) that competitively react with a peroxy radical and remove a free radical from the system (equation (11.6)). Also, the chain reaction may be terminated by self-quenching or pol)rmerization of free radicals to form non-radical dimers, trimers and polymers (equation (11.7)). [Pg.330]

Rhodopsin which is a brown [Red] coloured chromoprotein found in rods and synthesized from vitamin A, get bleached in presence of light and resynthesized in dark. The first step is the conversion of Rhodopsin into Bathorhodopsin after the absorption of light. This conversion needs only tens of picoseconds and each subsequent step is 10 -10 times slower than its previous step. Current opinion ascribes the changes to the inability of the straight all-trans-retinal to be sterically accommodated on the surface of the opsin, only bent 11-ds-retinal fitting into the protein. In the dark, the retinal in rhodopsin is in the 11-cis conformation. Absorption of photon leads to photoisomerisation of the double bond of the 11-ds-retinal in rhodopsin. This alters the configuration of the opsin and opsin changes activities of the associated hetero trimeric G protein, which is called transducin or Gt 1. Photoisomerisation leads to the formation of... [Pg.297]


See other pages where Vitamin Trimers is mentioned: [Pg.246]    [Pg.137]    [Pg.147]    [Pg.110]    [Pg.90]    [Pg.325]    [Pg.2604]    [Pg.268]    [Pg.56]   


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Trimers

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