Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Vitamin recycling

Clinical manifestation of vitamin B 2 deficiency is usually a result of absence of the gastric absorptive (intrinsic) factor. Dietary deficiency of vitamin B 2 is uncommon and may take 20 to 30 years to develop, even in healthy adults who foUow a strict vegetarian regimen. An effective enterohepatic recycling of the vitamin plus small amounts from bacterial sources and other contaminants greatly minimizes the risk of a complete dietary deficiency. Individuals who have a defect in vitamin B 2 absorption, however, may develop a deficiency within three to seven years. [Pg.112]

Approximately 0.05 to 0.2% of vitamin > 2 stores are turned over daily, amounting to 0.5—8.0 )J.g, depending on the body pool size. The half-life of the body pool is estimated to be between 480 and 1360 days with a daily loss of vitamin > 2 of about 1 )J.g. Consequentiy, the daily minimum requirement for vitamin B22 is 1 fig. Three micrograms (3.0 J.g) vitamin B22 are excreted in the bile each day, but an efficient enterohepatic circulation salvages the vitamin from the bile and other intestinal secretions. This effective recycling of the vitamin contributes to the long half-life. Absence of the intrinsic factor intermpts the enterohepatic circulation. Vitamin > 2 is not catabolized by the body and is, therefore, excreted unchanged. About one-half of the vitamin is excreted in the urine and the other half in the bile. [Pg.113]

Phenols are important antioxidants, with vitamin E being the most important endogenous phenolic membrane-bound antioxidant. Membrane levels of vitamin E are maintained through recycling of the vitamin E radical with ascorbate and thiol reductants. Vitamin E is a mixture of four lipid-soluble tocopherols, a-tocopherol being the most efiective radical quencher. The reaction of a-tocopherol with alkyl and alkylperoxyl radicals of methyl linoleate was recently reported. These are facile reactions that result in mixed dimer adducts (Yamauchi etal., 1993). [Pg.269]

D-Pantolactone and L-pantolactone are used as chiral intermediates in chemical synthesis, whereas pantoic acid is used as a vitamin B2 complex. All can be obtained from racemic mixtures by consecutive enzymatic hydrolysis and extraction. Subsequently, the desired hydrolysed enantiomer is lactonized, extracted and crystallized (Figure 4.6). The nondesired enantiomer is reracemized and recycled into the plug-flow reactor [33,34]. Herewith, a conversion of 90-95% is reached, meaning that the resolution of racemic mixtures is an alternative to a possible chiral synthesis. The applied y-lactonase from Fusarium oxysporum in the form of resting whole cells immobilized in calcium alginate beads retains more than 90% of its initial activity even after 180 days of continuous use. The biotransformation yielding D-pantolactone in a fixed-bed reactor skips several steps here that are necessary in the chemical resolution. Hence, the illustrated process carried out by Fuji Chemical Industries Co., Ltd is an elegant way for resolution of racemic mixtures. [Pg.86]

Vitamin B12 derivatives and their model compounds have recently been used as recyclable electrocatalysts for the reduction of alkyl halides since low-valent Co species are good nucleophiles toward organic substrates [367-369]. Examples of such elec-trocatalysts are the vitamin B12 derivatives aquocobalamin (230), dibromo[l-hydr-oxy-2,2,3,3,7,7,8,8,12,12,13,13,17,17,18,18-hexadecamethyl-10,20-diazaoctahydropor-phinato]cobalt(III) (231), and cobaloxim (232). The above Co(I) complexes can be... [Pg.548]

Figure 11.21 Outline of synthesis of phosphatidylinositol, phosphatidylserine, phosphatidylethanolamine and phosphatidylcholine. Note in the synthesis of phosphatidylinositol, the free base, inositol, is used directly. Inositol is produced in the phosphatase reactions that hydrolyse and inactivate the messenger molecule, inositol trisphosphate (IP3). This pathway recycles inositol, so that it is unlikely to be limiting for the formation of phosphatidylinositol bisphosphate (PIP )- This is important since inhibition of recycling is used to treat bipolar disease (mania) (Chapter 12, Figure 12.9). Full details of the pathway are presented in Appendix 11.5. Inositol, along with choline, is classified as a possible vitamin (Table 15.3). Figure 11.21 Outline of synthesis of phosphatidylinositol, phosphatidylserine, phosphatidylethanolamine and phosphatidylcholine. Note in the synthesis of phosphatidylinositol, the free base, inositol, is used directly. Inositol is produced in the phosphatase reactions that hydrolyse and inactivate the messenger molecule, inositol trisphosphate (IP3). This pathway recycles inositol, so that it is unlikely to be limiting for the formation of phosphatidylinositol bisphosphate (PIP )- This is important since inhibition of recycling is used to treat bipolar disease (mania) (Chapter 12, Figure 12.9). Full details of the pathway are presented in Appendix 11.5. Inositol, along with choline, is classified as a possible vitamin (Table 15.3).
Pharmacokinetics The parietal cells of the stomach secrete intrinsic factor, which regulates the amount of vitamin B-12 absorbed in the terminal ileum. Bioavailability of oral preparations is approximately 25%. Vitamin B12 is primarily stored in the liver. Enterohepatic circulation plays a key role in recycling vitamin B-12 from mainly bile. If plasma-binding proteins are saturated, excess free vitamin B- 2 will be excreted in the kidney. [Pg.11]

Severe cyanocobalamin (vitamin B12) deficiency results in pernicious anemia that is characterized by megaloblastic anemia and neuropathies. The symptoms of this deficiency can be masked by high intake of folate. Vitamin B12 is recycled by an effective enterohep-atic circulation and thus has a very long half-hfe. Absorption of vitamin B12 from the gastrointestinal tract requires the presence of gastric intrinsic factor. This factor binds to the vitamin, forming a complex that... [Pg.780]

Biotinidase (EC 3.5.1.12) is required for the recycling of biotin and for the utilization of protein bound biotin from the diet. Biotin (vitamin H) functions as a prosthetic group of four carboxylases in man the mitochondrial propionyl-CoA carboxylase,... [Pg.253]

Numerous dienes can be used as reactants, e.g., isoprene, myrcene, and famesene, and several compounds can be used as active methylene compounds. The reaction proceeds in an aqueous liquid-liquid system, with the conversion regulated by the time of contact between the phases, which is controlled by the stirring. The organic products are easily separated by simple decantation, and the aqueous phase containing the catalyst can be recycled. This reaction was industrialized to produce intermediates for vitamin E such as geranylacetone. The capadty is about 1000 tons/year. [Pg.499]

When present in excess methionine is toxic and must be removed. Transamination to the corresponding 2-oxoacid (Fig. 24-16, step c) occurs in both animals and plants. Oxidative decarboxylation of this oxoacid initiates a major catabolic pathway,305 which probably involves (3 oxidation of the resulting acyl-CoA. In bacteria another catabolic reaction of methionine is y-elimination of methanethiol and deamination to 2-oxobutyrate (reaction d, Fig. 24-16 Fig. 14-7).306 Conversion to homocysteine, via the transmethylation pathway, is also a major catabolic route which is especially important because of the toxicity of excess homocysteine. A hereditary deficiency of cystathionine (3-synthase is associated with greatly elevated homocysteine concentrations in blood and urine and often disastrous early cardiovascular disease.299,307 309b About 5-7% of the general population has an increased level of homocysteine and is also at increased risk of artery disease. An adequate intake of vitamin B6 and especially of folic acid, which is needed for recycling of homocysteine to methionine, is helpful. However, if methionine is in excess it must be removed via the previously discussed transsulfuration pathway (Fig. 24-16, steps h and z ).310 The products are cysteine and 2-oxobutyrate. The latter can be oxidatively decarboxylated to propionyl-CoA and further metabolized, or it can be converted into leucine (Fig. 24-17) and cysteine may be converted to glutathione.2993... [Pg.1389]

W. S. Letter, Preparative isolation of vitamin D2 from previtamin D2 by recycle HPLC, J. Chromatogr., 590 169 (1992). [Pg.102]

Kagan, V. et al., Ultraviolett light-induced generation of vitamin E radicals and their recycling. A possible photosensitizing effect of vitamin E in skin, Free Radical Res. Commun., 16, 51, 1992. [Pg.274]

Continued growth is expected in fermentation of glucose into saleable products, with the production of additional amino acids, vitamin feed additives, lactic acid or biopesticides.283 Not all companies will expand into these products. Ethanol production will continue to expand, but not at the rate that dry grind facilities did during the period from 2004-2007. For wet-mills, the addition of ethanol capacity will be as part of a waste treatment plan to minimize recycle streams. If polylactic acid284-287 becomes economically competitive, the demand for lactic acid could be explosive. [Pg.429]


See other pages where Vitamin recycling is mentioned: [Pg.323]    [Pg.134]    [Pg.2133]    [Pg.254]    [Pg.1296]    [Pg.1300]    [Pg.165]    [Pg.725]    [Pg.93]    [Pg.11]    [Pg.34]    [Pg.188]    [Pg.857]    [Pg.1286]    [Pg.140]    [Pg.141]    [Pg.175]    [Pg.134]    [Pg.9]    [Pg.371]    [Pg.43]    [Pg.330]    [Pg.858]    [Pg.161]    [Pg.422]    [Pg.58]    [Pg.67]    [Pg.23]    [Pg.346]    [Pg.1006]    [Pg.81]    [Pg.178]    [Pg.124]    [Pg.169]    [Pg.422]    [Pg.139]   
See also in sourсe #XX -- [ Pg.18 ]

See also in sourсe #XX -- [ Pg.473 ]




SEARCH



© 2024 chempedia.info