Vision, toxicological effects

Chronic exposure to GD causes forgetfulness, thinking difficulty, vision disturbances, muscular aches/pains. Although certain organophosphate pesticides have been shown to be teratogenic in animals, these effects have not been documented in carefully controlled toxicological evaluations for GD. 

H. H. Rengatorff (1985) Accidental exposure to sarin vision effects , Architecture Toxicology, 56,201-3. 

Properties Wh. cryst. powd. odorless bitter taste sol. in DMSO, abs. ethanol, methanol, methylene chloride, chloroform sol. 10-50 mg/ml in water, acetone m.w. 390.87 m.p. 130-135 C Toxicology LD50 (oral, rat) 306 mg/kg, (subcut., rat) 365 mg/kg, (IV, mouse) 26,100 pg/kg, (IP, mouse) 76,700 pg/kg highly toxic by ing., IP, subcut., IV routes causes CNS effects in humans exposure to Ig. amts, may cause hallucinations, convulsions, death may cause drowsiness, dizziness, sleeplessness, nervousness, excitability, sensitivity reactions, dry mouth, weakness, anorexia, nausea, vomiting, headache, hypotension, polyuria, heartburn, diplopia, dysuria, blurred vision, dermatitis... 

Properties Orthorhombic need., odorless, intense bitter taste sol. 1 g/1900 ml water, 0.8 ml alcohol, 80 ml benzene, 1.2 ml chloroform, 20 ml glycerol, 1900 ml of 10% ammonia water almost insol. in petroleum ether m.w. 324.43 m.p. 175 C (dec.) Toxicology LDLo (oral, rat) 800 mg/kg, (subcut., rat) 200 mg/kg, (IP, rat) 115 mg/kg, (IV, rabbit) 70 mg/kg poison by subcut., IV, IP, intramuscular routes mod. toxic by ing. human poison skin and mucous membrane irritant ing. of pure substance adversely affects eyes can cause temporary loss of vision human systemic effects by ing. (tinnitus, nausea, vomiting) experimental teratogen, reproductive effects human teratogenic effects mutagenic data TSCA listed... 

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