Viruses interaction with chemical agents

DiPaolo JA, Casto BC. 1976. In vitro transformation-interaction of chemical carcinogens with viruses and physical agents. Int Agency Res. Cancer Scientific Publications 12 415-432. 

Research work on the mode of action of these compounds furnished the theoretical basis for the chemical control of insects by means of chemosterilants, and most of the compounds showing such action were first described as antitumour agents. In no other field is the interaction between plant protection and human therapy so close as that between the chemotherapy of cancer and insect control by chemosterilants. The capacity of these substances to interfere with the biosynthesis of DNA served as the common theoretical basis. In addition to other effects such as antitumour and antimitotic effects, deactivation of viruses, etc., a characteristic outcome of this interference is the mutagenic effect and, closely related to this, inhibition of reproduction (Bofkovec, 1962). 

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