Virus site directed

De Vreese K, Debyser Z, Vandamme A-M, Pauwels R, Desmyter J, De Clercq E, Anne J. Resistance of human immunodeficiency virus type 1 reverse transcriptase to TIBO derivatives induced by site-directed mutagenesis. Virology 1992 188 900-904. 

Giraud, C., Winocour, E. and Berns, K. I. (1994). Site-specific integration by adeno-associated virus is directed by a cellular DNA sequence. Proc. Natl. Acad. Sci. USA 91, 10039-10043. 

Culver, J. N., Dawson, W. O., Plonk, K., and Stubbs, G. (1995). Site-directed mutagenesis confirms the involvement of carboxylate groups in the disassembly of tobacco mosaic virus. Virology 206, 724-730. 

Hahn, C. S., and Strauss, J. H. (1990). Site-directed mutagenesis of the proposed catalytic amino acids of the Sindbis virus capsid protein autoprotease. J. Virol. 64, 3069-3073. 

Similarly, Chong et al. [22] showed that a positively charged residue was involved in substrate binding and hydrolysed by an influenza virus NA. Using site-directed mutagenesis, Lentz et al. [23] identified amino acids involved in enzyme activity without the full knowledge of the NA three-dimensional structure. Although the enzyme mechanism proposed by Lentz is... 

Detailing the function of the molecule then additionally involves substrate or inhibitor (drug) binding in the cases of enzymes or viruses and/or site directed mutagenesis of a protein and subsequent X-ray analysis. Sophisticated technologies are used which include ... 

Mapping alpha-helical induced folding within the intrinsically disordered C-terminal domain of the measles virus nucleoprotein by site-directed spin-labeling EPR spectroscopy. Proteins 73 973-988... 

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