Viral subversion

Thomson JA, Perni RB (2006) Hepatitis C virus NS3-4A protease inhibitors countering viral subversion in vitro and showing promise in the clinic. Curr Opin Drug Discov Devel 9 606-617... 

A. Alcami and U. H. Koszinowski, Viral mechanisms of immune evasion, Trends in Microbiology, 8, 2000, 410-18 D. Tortorella et al., Viral subversion of the immune system, Annual Review of Immunology, 18, 2000, 861-926. 

Tortorella D, Gewurz BE, Furman MH et al. Viral subversion of the immune system. Annu Rev Immunol 2000 18 861-926. 

Viral Subversion of TLR Signalling More ThanJust Inhibition... 

The HATs belonging to the MYST family play essential roles in a wide variety of critical cellular processes. Further research will undoubtedly reveal additional functions of these enzymes that profoundly impact cellular growth, differentiation and replication. It is not surprising, therefore, that their malfunctions or subversion of their regular functions by cellular or viral machinery have been linked to a number of human diseases. A comprehensive understanding of these mechanisms is crucial to design of successful therapies, such as small-molecule inhibitors, that will be able to specifically target the undesirable activities of MYST HATs. 

Murphy, P. M. (2001). Viral exploitation and subversion of the immune system through chemokine mimicry. Nat. Immunol. 2, 116-122. 

Thus there is a complex relationship between TLRs and viruses and viral immunomodula-tion of TLRs encompasses not only inhibition of signallii pathways for evasion, but also their hijacking and subversion. 

Constitutively Active Viral Chemokine Receptors Tools for Immune Subversion and Pathogenesis... 

The control of protein synthesis, either by regulation of the amount of mRNA available for translation or by the efficiency with which it is translated, is important in cell growth and development as a factor determining the level of cellular and extracellular proteins. Subversion of this control occurs in cells infected by viruses when the viral... 

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