Vira-A - Vidarabine

Spongoadenosine (Ara-A, Vira-A) Vidarabin, Vira-A Cryptotethya crypta Sponge Antiviral (herpes) Arabinoside 1972... 

Vidarabine (adenine arabinoside, Vira-A) is an adenine nucleoside analogue containing arabinose in place of ri-bose. It is obtained from cultures of Streptomyces an-tibioticus and has activity against HSV-1, HSV-2, VZV, CMV, HBV, poxviruses, hepadnaviruses, rhabdoviruses, and certain RNA tumor viruses. 

Drug interactions There are no known drug interactions with Adagen. However, the antiviral agent vidarabine (Vira-A) is a substrate for ADA and 2 -deoxyco-formycin (Pentostatin) is a potent inhibitor of ADA. Thus the activities of these drugs and Adagen could be substantially altered if they are used in combination with one another. 

Vidarabine Vira-A Local (ophthalmic] administration for treatment of herpes simplex keratoconjunctivitis... 

Antiviral Efficacy and Clinical Use. Vidarabine (Vira-A) was the first systemic agent used to treat herpesvirus infections, including CMV, herpes simplex virus, and varicella-zoster virus.42 In the past, this drug was administered by continuous intravenous infusion to treat severe systemic infections caused by these viruses, but systemic use of vidarabine has been replaced by safer and less toxic agents. Vidarabine is currently used primarily to treat local viral infections of the eye (e.g., herpes simplex keratoconjunctivitis) it is applied topically by ophthalmic ointment to treat these infections. 

Vidarabine, once marketed under the trade name Vira-A , has been discontinued by the manufacturer and is only available through compounding pharmacies. Vidarabine may be effective in cases that fail to respond to idoxuridine or in rare cases of hypersensitivity to trifluridine. 

Vibramycin doxycycline. vidarabine [ban. inn. jan. usan) (adenine arabinoside Ara-A Vira-A ) is a purine nucleoside ANTIVIRAL isolated from the marine gorgonian Evnicella cavoUni and Streptomyces spp. Clinically, it may be used to treat herpes simplex and vaccinia infections. 

Chloramphenicol (Chloromycetin Ophthalmic) Ciprofloxacin (Cipro) Erythromycin Gentamicin sulfate (Garamycin Ophthalmic) Norfloxacin (Chibroxin) Tobramycin (Nebcin, Tobrex) Natamycin (Natacyn Ophthalmic Idoxuridine (IDU) Trifluridine (Viroptic) Vidarabine monohydrate (Vira-A) Dexamethasone Diclofenac Na (Voltaren) Suprofen Profenal) Ketorolac tromethamine (Acular) Olopatadine HCL Ophthalmic solution Medrysone (HMS Liquifilm) Prednisolone acetate Prednisolone Na phosphate Combination TobraDex... 

Vidarabine (vira-a) Topical (3% ointment) PK, H Herpes simplex keratitis and conjunctivitis... 

Vidarabine (Vira A) Phosporylated metabolite inhibits viral DNA polymerase. Inhibits mammalian DNA polymerase to lesser extent. Herpes simplex encephalitis, herpes zoster. 

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