Vinyl Polymers Containing Nucleic Acid Bases

Vinyl Polymers Containing Nucleic Acid Bases 

methacryl groups, or their derivatives were introduced to the 1-position of pyrimidine (cytosine, uracil, and thymine) or 9-position of purine (adenine, guanine, and hypoxanthine) to yield the vinyl monomers, which were polymerized with the aid of radical initiators in organic solvents 

Most of these radical polymerizations proceeded very rapidly and the yields of the polymerization were very high even though the vinyl monomers contained pyrimidine or purine bases. As these PNAs did not contain sugar rings or hydrophilic groups, most of them were insoluble in water. Their properties were therefore investigated mainly in organic solvents. Synthesis of the monomer and the polymerizations were well summarized in the reviews [2, 3]. 

Functional Polymers Coupled with Nucleic Add Base Derivatives 

---

Vinyl Polymers Containing Nucleic Acid Bases... 

The chemistry of vinyl-type polymers containing nucleic acid bases as nucleic add models has recently been given considerable attention. A number of such synthetic polymers has been designed and synthesized, and their functions have been extensively studied because, in contrast to polynucleotides, their backbone structure exhibits the following characteristics ... 

Synthesis.—A number of interesting developments in synthetic techniques have taken place recently. The use of template polymerization has up to now been confined to vinyl polymerization and the preparation of polypeptides from the A-carboxyanhydrides of amino-acids. The template polycondensation of active esters containing nucleic acid bases with diamines has been reported. The enantioselective ester synthesis in the presence of optically active polymers, a not dissimilar process to template polymerization, has also been reported. ... 

---