Vincent s infection

Trench mouth (necrotizing ulcerative gingivitis), also called Vincent s infection, usually affects young adults and is considered a form of periodontal disease. If untreated, it can lead to the loss of gum tissue and eventually loss of teeth. Today, there are more effective treatments for trench mouth than KMnO,. 

Alternative therapy for the following infections when penicillin is contraindicated Uncomplicated gonorrhea due to Neisseria gonorrhoeae] syphilis due to Treponema pallidum, yaws due to T. pertenue] Listeria monocytogenes] anthrax due to Bacillus anthracis] Vincent s infection due to Fusobacterium fusiforme] actinomycosis due to Actinomyces sp. Clostridium sp. 

Orodental infection caused by mixed aerobic, anaerobic bacteria including Vincent s infection caused by Fusobac-terium. Tetracycline also prove to be beneficial in peridontal inflammation by scavenging free radicals. Its use in pregnancy, lactation and in children is contraindicated. Its use in dentistry is very much restricted due to its chelating effect on teeth and bones. 

Vincent s infection (microbiologically complex, includes anaerobes, spirochaetes) responds readily to benzylpenicillin a single i.m. dose of 600 mg is often enough except in a mouth needing dental treatment, when relapse may follow. Metronidazole 200 mg 8-hourly by mouth for 3 days is also effective. 

More recently, organoarsenical compounds were used in the treatment of amebiasis, worms, trichomonas vaginalis, Vincent s angina, and even other ORL infections (Table 3). 

Bailey, J.A., G.G. Vincent, and R.S. Burden The antifungal activity of glutinosone and capsidiol and their accumulation in virus-infected tobacco species Physiol. 

R. S. Burden, J. A. Bailey and G. G. Vincent, "Glutinosone, A New Antifungal Sesquiterpene from Nicotlana glutlnosa Infected with Tobacco Mosaic Virus", Phytochemistry, lA, 221-223 (1975). 

Fourtillan JB, Granier J, Saint Salvi B, Salmon), Surjus A, Tremblay D, Vincent du Laurier M, Beck S. Pharmacokinetics of ofloxacin and theophylline alone and in combination. Infection (1986) 14 (Suppl 1), S67-S69. 

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