Vinblastine pulmonary toxicity

VINBLASTINE MITOMYCIN-C t risk of abrupt onset of pulmonary toxicity in 3-6% of patients, when two courses of these drugs are administered concurrently Mechanism is uncertain possible additive pulmonary toxic effects Monitor clinically and with lung function tests for pulmonaiy toxicity. Advise patients to report immediately symptoms such as shortness of breath and wheezing... 

Konits PH, Aisner J, Sutherland JC, Wiernik PH. Possible pulmonary toxicity secondary to vinblastine. Cancer 1982 50(12) 2771-4. 

Hoelzer KL, Harrison BR, Luedke SW, Luedke DW. Vinblastine-associated pulmonary toxicity in patients receiving combination therapy with mitomycin and cisplatin. Drug Intell Clin Pharm 1986 20(4) 287-9. 

Vinblastine and vindesine can increase the pulmonary toxicity of mitomycin C. Severe and life-threatening bronchospasms and two cases of fatal acute respiratory failure have been reported. 

Myelosuppression may be delayed and prolonged (up to 8 weeks) mucositis moderately emetogenic extravasation severe vesicant pulmonary toxicity pneumonitis, fibrosis (worse with concurrent vincristine or vinblastine) hemolytic anemia and uremic syndrome... 

A syndrome of acute pulmonary toxicity, characterised by severe shortness of breath, can occur when vinblastine, vindesine or vinorelbine is given with mitomycin. Fatalities have occurred. 

Ozols RF, Hogan WM, Ostchega T, Young RC. MVP (mitomycin, vinblastine, progesterone) a second-line regimen in ovarian cancer with a hi incidence of pulmonary toxicity. Cancer Treat Rep ( 9Zy) 67,721-2. 

Rarely, azathioprine and its major metabohte 6-mercaptopurine have been reported to produce an acute restrictive lung disease. Procarbazine, a methylhydrazine associated more commonly with Loef-fler s syndrome, rarely has been associated with pulmonary fibrosis. The vinca alkaloids vinblastine and vindesine have been reported to produce severe respiratory toxicity in association with mitomycin. The incidence with the combination is 39% and may represent a true synergistic effect between these agents. ... 

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