Vibrio damsela

All of the above SMases are C type SMases that produce Cer and choline phosphate an SMase D (which produces Cer 1-phosphate and choline) is found in the venom of brown recluse spider, Corynebacterium pseudotuberculosis (which commonly infects sheep). Vibrio damsela (an aquatic bacterium that causes wound infections in humans), and the human pathogen Arcanobacterium haemolyticum. The venom SMase D produces much of the tissue damage caused by these organisms (A.P Truett, 1993) by sustained activation of inflammation (S.H. Farsky, 2005). Interestingly, SMase also acts as a lysophosphatidylcholine phosphodiesterase to produce lysophosphatidic acid, another inflammatory mediator (L.A. van Meeteren, 2004). 

EiGUERAs A, SANTAREM MM, NovoA B. Influence of the sequence of administration of P-glucans and a Vibrio damsela vaccine on the immune response of turbot Scophthalmus maximus L.). Vet Immunol Immunopathol 1998,64, 59-68. 

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