Vesicular stomatitis virus host restricted

MBBK (Madin-Darby Bovine Kidney) cells are an established line of male bovine cells. Although restrictive for mengovirus replication, they have been used as a productive host for the WSN strain of influenza virus (21) and for vesicular stomatitis virus... 

It has been realized for some time that viral multiplication can occur with only minimal cytopathic effects (Choppin, 1964). Conversely, considerable cytopathology can result from infection with a virus, the multiplication of which is restricted in that host. Cantell et al. (1962) were perhaps the first to describe that L cells could be destroyed by large doses of a UV-irradiated virus, vesicular stomatitis virus, in the absence of a detectable synthesis of viral antigen this toxic activity could not be separated from the viral particle. We shall discuss in a later chapter why this does not prove the absence of viral replicative functions or that preformed virion components are necessarily cytotoxic. However, it is quite clear that early interactions... 

Obijeski, J. F., and Simpson, R. W., 1974, Conditional lethal mutants of vesicular stomatitis virus. II. Synthesis of virus-specific polypeptides in nonpermissive cells infected with RNA host-restricted mutants. Virology 57 369. 

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