Vascular dementia cognitive impairment

Dubois MF, Hebert R (2001) The incidence of vascular dementia in Canada a comparison with Europe and East Asia. Neuroepidemiology 20 179-187 Englund E (2002) Neuropathology of white matter lesions in vascular cognitive impairment. Cerebrovasc Dis 13 [Suppl 2] 11-15... 

Rockwood K, Burns A, Gauthier S, DeKosky ST (2003) Vascular cognitive impairment. Lancet Neurol 2 89-98 Roman GC (1987) Senile dementia of the Binswanger type. A vascular form of dementia in the elderly. JAMA 258 1782-1788... 

Non-cognitive disturbances are common in patients with vascular cognitive impairment, with high rates of depression and apathy, particularly in those with small vessel disease. For example, in the Cache County Study, significantly more participants with vascular dementia (32%) than Alzheimer s disease (20%) suffered from depression, the reverse being true for... 

Barnes DE, Alexopoulos GS, Lopez OL et al. (2006). Depressive symptoms, vascular disease, and mild cognitive impairment findings from the Cardiovascular Health Study. Archives of General Psychiatry 63 273-279 Bastos-Leite AJ, van der Flier WM, van Straaten EC et al. (2007). The contribution of medial temporal lobe atrophy and vascular pathology to cognitive impairment in vascular dementia. Stroke 38 3182-3185 Black S, Roman GC, Geldmacher DS et al. (2003). Efficacy and tolerability of donepezil in vascular dementia positive results of a 24-week, multicenter, international, randomized, placebo-controlled clinical trial. Stroke 34 2323-2330... 

Dementia after stroke is a predictor of long-term survival. Stroke 25 1915-1919 Wentzel C, Rockwood K, MacKnight C et al. (2001). Progression of impairment in patients with vascular cognitive impairment without dementia. Neurology 57 714-716 Wilkinson D, Doody R, Helme R et al. (2003). Donepezil in vascular dementia a randomized, placebo-controlled study. Neurology 61 479-486... 

Besides their use in Alzheimer s disease, cholinesterase inhibitors have been extended to treat other dementias and related illnesses, which may include vascular dementia, dementia with Lewy Bodies, dementia associated with Parkinson s, mild cognitive impairment, and mixed dementia. Research is particularly important in this area since it is not uncommon for Alzheimer s disease to be co-morbid with other types of dementia. Therefore, it is important to devote a section briefly discussing recent flndings and the use of... 

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