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Varenicline

Obach, R. S., Reed-Hagen, A. E., Krueger, S. S., Obach, B. J., O Connell, T. N Zandi, K. S Miller, S Coe, J. W. Metabolism and disposition of varenicline, a selective alpha4beta2 acetylcholine receptor partial agonist, in vivo and in vitro. Drug Metab. Dispos. 2006, 34, 121-130. [Pg.432]

Varenicline FDA approved in 2006 Titrate up to 1 mg orally twice daily 3-6 months Monitor renal function, especially in elderly patients. Nausea, headache insomnia are dosedependent adverse effects. Al... [Pg.850]

Varenicline is a partial agonist that binds selectively to nicotinic acetylcholine receptors with a greater affinity than nicotine, thus producing an attenuated response compared to that of nicotine. Its place in therapy has not been established. [Pg.851]

Jorenby DE, Hays JT, Rigotti NA, Azoulay S, Watsky EJ, Williams KE, et al (2006) Efficacy of varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs placebo or sustained-release bupropion for smoking cessation a randomized controUed trial. JAMA 296(l) 56-63... [Pg.140]

Cytisine and varenicline are partial agonists with activity at the o4p2 binding site. In tests of nicotine discrimination, pretreatment with cytisine has no... [Pg.312]

Varenicline increases smoking cessation rates in smoking cessation trials and appear to prevent relapse. [Pg.354]

Q59 Cigarette smoking should stop completely before starting varenicline. Varenicline may cause dry mouth, taste disturbance and aphthous stomatitis as side-effects. [Pg.145]

Varenicline is a selective nicotine receptor partial agonist that is used in smoking cessation. It is started 1-2 weeks before target stop date. It may cause gastrointestinal disturbances, dry mouth, taste disturbance and, less commonly, aphthous stomatitis. [Pg.164]

Cytisine (30) Varenicline (31) Quinolizidine alkaloid Smoking cessation... [Pg.22]

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Production of Nicotine and Varenicline

Scale varenicline

Smoking cessation, varenicline treatment

Varenicline - an Anti-smoking Drug

Varenicline efficacy

Varenicline syntheses

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