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Smoking cessation, varenicline treatment

Varenicline, a small (molecular weight 211.27) achiral alkaloid, was identified in 1997 as a potential treatment for smoking cessation. Its selection as our clinical candidate came after years of effort to identify an effective and safe partial agonist selective for the a4(32 nAChR subtype. A majority of the analogs explored in the course of our work were structurally related to the natural product (-)-cytisine and variations thereof.The discovery synthesis shown in Scheme 3.1 is rooted in... [Pg.24]

See other pages where Smoking cessation, varenicline treatment is mentioned: [Pg.508]    [Pg.547]    [Pg.114]    [Pg.162]    [Pg.352]    [Pg.427]    [Pg.487]    [Pg.647]    [Pg.232]    [Pg.77]    [Pg.23]    [Pg.721]   
See also in sourсe #XX -- [ Pg.245 ]



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Cessation

Cessation treatments

Smoking cessation

Varenicline

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