Vane, John

Ferdinand Rodriguez, Leland M. Vane, John J. Schlueter, and Peter Clark... 

Much of the fundamental work on prostaglandins and related compounds was car ried out by Sune Bergstrom and Bengt Samuelsson of the Karohnska Institute (Sweden) and by Sir John Vane of the Wellcome Foundation (Great Britain) These three shared the Nobel Prize for physiology or medicine m 1982... 

Bengt Samuelsson (1934-) was born in Halmstad, Sweden, and received both Ph.D. (1960) anti M.D. (19611 degrees from the Karolinska Institute, where he worked with Sune Bergstrom. He remained at the Karolinska Institute as professor and shared the 1982 Nobel Prize in medicine with Bergstrom and John R. Vane. 

Botting RM (2006) Cyclooxygenase past, present and future. A tribute to John R. Vane (1927-2004). J Therm Biol 31 208-219... 

It is an unfortunate consequence of the use of Christian name abbreviation (A. Spirin), that Alex always evokes for me a well known analgesic, antipyretic and antiinflammatory agent, which John Vane showed in 1971 to be an inhibitor of the synthesis of prostaglandins from arachadonic acid. 

Like nitric oxide, the discovery of the eicosanoid signalling molecules was a significant event in twentieth century physiology, due largely to research led by Sir John Vane (Nobel Prize 1982). The diverse actions of the eicosanoids include roles in muscle contraction, blood coagulation, salt and fluid homeostasis, inflammatory responses and pain sensitivity. 

In the 1970s, John Vane discovered the mechaiusm of action of NS AlDs, inhibition of COX, an accomplishment rewarded with a share of the Nobel Prize in Physiology or Medicine for 1982. 

The thromboxanes have a six-membered ring containing an ether. They are produced by platelets (also called thrombocytes) and act in the formation of blood clots and the reduction of blood flow to the site of a clot. The nonsteroidal antiinflammatory drugs (NSAIDs)— aspirin, ibuprofen, and meclofenamate, for example— were shown by John Vane to inhibit the enzyme prostaglandin H2 synthase (also called cyclooxygenase or COX), which catalyzes an early step in the pathway from arachidonate to prostaglandins and thromboxanes (Fig. 10-18 see also Box 21-2). 

Sune K. Bergstrom, Bergt I. Samuelsson, and John R. Vane Physiology/Medicine Isolation and study of prostaglandins... 

The biochemical paths and actions by which aspirin and other salicylates achieve their therapeutic effects were poorly understood until at least a partial mechanism w as proposed by Sir John Vane in 1971. Vane, who later received a Nobel Prize for his efforts (1982), found that NSAIDs, including aspirin, block the production of prostaglandins by cells and tissues. During the same time frame. Vane and other researchers also confirmed the inhibitory effects of aspirin on platelet aggregation, this caused by interference with the ability of platelets to synthesize prostaglandins, notably thromboxane A2. The complexities of the topic go well beyond the scope of this volume, but are well ventilated in the Vane (1971), the Smith-Willis (1971). and the Weissmann (1991) articles listed, See also Prostaglandins,... 

British pharmacologist John R. Vane discovers that aspirin works by reducing the formation of prostaglandins and therefore reducing pain. He is awarded the Nobel Prize for this discovery in 1982. 

Holocaust disputed sole activity Sir John Vane... 

Aspirin is the most widely used pain reliever and antiinflammatory agent in the world, yet its mechanism of action remained unknown until the 1970s. John Vane, Bengt Samuelsson, and Sune Bergstrom shared the 1982 Nobel Prize in Physiology or Medicine for unraveling the details of its mechanism. 

However, the story was not over. About 80 years after the introduction of Aspirin as a pain reliever, it was established that acetylsalicylic acid prevents heart attacks and strokes and reduces the risk of death during a suspected heart attack. In 1982, John R. Vane was awarded the Nobel Prize for medicine for discovering the basic mechanism of the action of acetylsalicylic acid. 

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