Valproic acid children

U.S. Expert Panel 2005 Valproic acid Carbamazepine Lamotrigine Oxcarbazepine Phenobarbital Phenytoin Topiramate Valproic acid Children Carbamazepine Phenobarbital Phenytoin Topiramate Valproic acid Lamotrigine... 

Kastnet, T, and Ftiedman, D.L. (1992) Verapamil and valproic acid treatment of ptolonged mania. / Am Acad Child Adolesc Psychiatry 31 271-275. 

FIGURE 43.1 Pharmacologic treatment algorithm for full syndrome pediatric PTSD. Based on a snythesis of consensus data and clinical reports in the adult and child literature. The author hers no responsibility for the use of this guideline by third parties. SSRI, selective serotonin reuptake inhibitor NEE, nefaza-done SIB, self injurious behavior VLF, venlafaxine VPA, valproic acid. 

Valproic acid can have unacceptable side effects, such as hair loss, weight gain, and sedation. Certain problems can limit valproic acid s usefulness in women of child-bearing potential, including the fact that it can cause neural tube defects in... 

Gara L, Roberts W. Adverse response to methylphenidate in combination with valproic acid. J Child Adolesc Psychopharmacol 2000 10(1) 39 3. 

A child with developmental delay and epilepsy developed glycosuria about 16 months after starting to take valproic acid (90). Laboratory evaluation showed global defects in proximal tubule function, consistent with the De Toni-Debre-Fanconi syndrome. The authors reviewed the literature on this rare complication, which is reversible on valproate withdrawal. 

Herranz JL, Arteaga R, Armijo JA. Change in hair colour induced by valproic acid. Dev Med Child Neurol... 

Gara L +, 7 Child Adolesc Psychopharmacol 10, 39 (with valproic acid)... 

Recently it was described that an 11-year-old boy who developed status epilepticus after a prolonged right-side simple partial motor seizure, which was unresponsive to long-term aggressive treatment with several AEDs [51]. The control of seizures was achieved at a plasma valproic acid level of 108 pg/ml, but electrical status epilepticus persisted, and the child remained comatose. On day 37, a treatment with verapamil (a calcium L-channel blocker) was started, and 1.5 h after the initiation of the infusion, the patient regained consciousness, breathed spontaneously, and the electrical status promptly disappeared. The authors suggested that verapamil, a... 

Chez MG, Hammer MS, Loeffel M, et al. Clinical experience of three pediatric pahents and one adult case of spike and wave status epilepticus treated with injectable valproic acid. J Child Neurol 1999 14 239-242. 

Bertoldo M. Valproic acid and risperidone. J Am Acad Child Adolesc Psychiatry (2002) 41, 632. 

Castro-Gago M, G6mez-Lado C, Eirfs-Punal J, Dfaz-Mayo I, Castineiras-Ramos DE. Serum biotinidase activity in children treated with valproic acid and carbamazepine. J Child Neurol 2010 25 (1) 32-5. 

Gokqe S, Durmaz O, Celtik C, Aydogan A, Gtilluoglu M, Sbkiicu S. Valproic acid-associated vanishing bile duct syndrome. J Child Neurol 2010 25(7) 909-11. 

Veenstra-VanderWeele J. Increase in valproic acid levels during riluzole treatment in an adolescent with autism. J Child Ado-lesc Psychopharmacol 2010 20(2) 163-5. 

Susceptibility factors Genetic A 5-year-old child died after being given hydrocodone bitartrate 1 mg/ml, 1 teaspoon tds [97" ]. Genetic analysis showed that the child had reduced ability to metabolize hydrocodone via CYP2D6. Co-administration of clarithromycin and valproic acid had further reduced drug elimination, leading to accumulation of lethal concentrations. 

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