Use and Misuse

Klit, P., Jensen, F. and Ellevang, P. 1993 Reliable Design Methodology - the use and misuse of reliability data in the design process. In Proceedings ICED 93, The Hague, 1156-1164. 

J. E. Finchman, Over-the-counter drug use and misuse by the ambulatory elderly A review of the literature, J. Geriatr. Drug Ther., 1, 3 (1986). 

Weiss N (1997) The Hill equation revisited Uses and misuses. FASEB J 11 835—841. 

Opiates have been available for 4,000 years or more - describe the changing pattern of use and misuse throughout history. 

Drug use and misuse - an overview of some core issues... 

Steffen T, Christen S, Blattler R and Gutzwiller F (2001). Infectious diseases and public health Risk taking behaviour during participation in the Swiss Programme for a Medical Prescription of Narcotics (PROVE). Journal of Substance Use and Misuse, 36, 71-89. 

Flexible PU Foam, Its Uses and Misuses British Rubber Manufacturers Association, London 1976 revised 1983. 

Stinchfield, R., Winters, K. C. (1997). Measuring change in adolescent drug misuse with the Personal Experiences Inventory (PEI). Substance Use and Misuse, 32, 63-76. 

Adrian M (2001). Do treatments and other interventions work Some critical issues. Substance Use and Misuse, 36, 1759-80 Advisory Council on the Misuse of Drugs... 

Green L Gossop M (1988). Effects of information on the opiate withdrawal syndrome. British Journal of Addiction, 83, 305-9 Green B, Young R Kavanagh D (2005). Cannabis use and misuse prevalence among people with psychosis. British Journal of Psychiatry, 187, 306-13... 

Jauffret-Roustide M, Emmanuelli M, Barin F, Arduin P, Laporte A Desenclos JC (2006). Impact of a harm-reduction policy on HIV and hepatitis C virus transmission among drug users recent French data—The ANRS-Coquelicot study. Substance Use and Misuse An International Interdisciplinary Forum, 41, 1603-21... 

Amphetamine is a racemic mixture of phenylisopropylamine (Figure 9-4) that is important chiefly because of its use and misuse as a central nervous system stimulant (see Chapter 32). Pharmacokinetically, it is similar to ephedrine however, amphetamine even more... 

Propoxyphene is chemically related to methadone but has low analgesic activity. Various studies have reported its potency at levels ranging from no better than placebo to half as potent as codeine that is, 120 mg propoxyphene = 60 mg codeine. Its true potency probably lies somewhere between these extremes, and its analgesic effect is additive to that of an optimal dose of aspirin or acetaminophen. However, its low efficacy makes it unsuitable, even in combination with aspirin, for severe pain. The increasing incidence of deaths associated with its use and misuse has caused it to be scheduled as a controlled substance. Moreover, banning its use in the United States is under consideration. 

Two statistical terms involving error analysis that are often used and misused are accuracy and precision. Precision refers to the extent of agreement among repeated measurements of an experimental value. Accuracy is defined as the difference between the experimental value and the true value for the quantity. Since the true value is seldom known, accuracy is better defined as the difference between the experimental value and the accepted true value. Several experimental measurements may be precise (that is, in close agreement with each other) without being accurate. 

A wide range of possible uses and misuses must be considered in both the development of formulations and in regulatory decisions. Formulations need to be tested as they might be used, not just as they are meant to be used. While it is possible to develop formulations that lower the abuse potential of a pharmacological constituent, every effort must be made to challenge the formulation to substantiate such a claim. 

Stahl, S.M. (1999) Antipsychotic polypharmacy, part 2 Tips on use and misuse. Journal of Clinical Psychiatry 60(8), 506—7. 

T.D. Arias, L.F. Jorge, R. Barrantes, Uses and Misuses of Definitions of Genetic Polymorphism. A Perspective from Population Pharmacogenetics , Br. J. Clin. Pharmacol., 31,117-118 (1991). 

GHB Its Use and Misuse. Harvard Mental Health Letter 17 (March 2001) 7-8. 

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