Urinary indican

Origin of Urinary Indican, Indigo, Indiruhin, Skatoxyl, and Skatole Red... 

Urinary indican is the 0-sulfate of indoxyl (usually isolated as the potassium salt, 414) and is excreted by mammals as a detoxication product of the... 

Potassium salt, C,H,KNOJS, indol-3-yl potassium sulfate, urinary indican, potassium indoxyl sulfate. Light brown plates from aq ale, dec 179-180 with sublimation. Very sol in water practically insol in cold alcohol. 

As it often happens, a decisive piece of information came from an entirely different quarter. In 1879, Baumann and Tiemann had isolated urinary indican. This is the potassium salt of indoxyl sulfate, which arises in the urine under... 

Indoxyl, urinary indican, indigo, indirubin (D 21) Urine... 

A compound formed by the action of bacteria in the gut on dietary tryptophan. It is absorbed from the gut and subsequently excreted in the urine. Increased bacterial activity in the gut (e.g. in blood loop syndrome or inestinal stagnation) results in increased urinary indican excretion. 

An adolescent developed a persistent scaly and dirty-looking rash and severe neurologic symptoms, such as difficulty in walking and maintaining balance. He was in and out of the hospital for several years with no relief. His laboratory data showed increased levels of serum bicarbonate (31 meq/L), normal urinary porphyrins and porphobilinogen, and a massive excretion of amino acids, indican, and indoxyl sulfate. 

Indole absorbed from the gut is hydroxylated to form indoxyl, which conjugates with sulfate to produce indican (indoxylsulfuric acid) in the liver. Indoxyl and indican are found in human plasma and urine. The daily urinary excretion of indoxylsulfate in normal adults was reported to average 200 mg (range 140-250 mg). Indole was not detected in the blood of rabbits exposed at 10mgm for 3h. 

Urinary indole profile Larger excretion of 5-hydroxyindole acetic acid, 5-hydroxy tryptamine, and kynurenine are consistently present but indican is absent 48,135, 229... 

This observation suggests that the urinary substance giving rise to the atypical indican test was not derived from dextrorotary intermediates arising in the biosynthesis of histidine. 

This consists of p-dimethylaminobenzaldehyde in hydrochloric acid. It is used in the estimation of urinary urobilinogen (which gives a red colour), porphobilinogen, (giving a red colour which can be extracted into organic solvents) and indican (when the red chromogen can be extracted into alkali). 

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