Urea, cyclohexyl

Unsolvated -butylmagnesium CHLORIDE, 47,112 Urea, cyclohexyl-, 45, 69 Urea, 1-(2,6-dimethylpiienyl)-2-T1I10-, 45, 70... 

Glipi de. GHpi2ide (l-cyclohexyl-3[ -[2-(5-methylpyra2inecarboxamido)eth5l]phenyl]sulfonyl]urea), mol wt 445.55, forms crystals from ethanol, mp 208—209°C. It is known commercially as Glucotrol. 

Chemical Name 1-cyclohexyl-3-[ [p-[2-(5-methylpyrazinecarboxamido)ethyl] phenyl] -sulfonyl] urea... 

CN ( )-A/-cyclohexyl-/V -[4-[3-[(l,l-dimethylethyl)amino]-2-hydroxypropoxy]phenyl]urea... 

C,7H, N20 93271-68-2) see Praziquantel l-cyclohexyl-5-(4-chlorobutyl)tetrazole (C, H C1N4 73963-42-5) see Cilostazol cyclohexylglyoxylic acid (CSH12O3 4354-49-8) see Cetiedil iV-cyclohexyl-AP-(2-hydroxyethyl)urea (C5HisN202 66929-46-2) see Lomustine... 

Poly(urethane urea)polysulfide resins consisting of polycaprolactone diol, 4,4 -methylenebis(cyclohexyl isocyanate), and bis-epithiopropyl sulfide, were prepared by Bojkova et al. (4) and used as optical lenses having good refractive index and good impact resistance/strength. 

Table VII (51). The relevant free dimensions are often similar for zeolite and nonzeolite. Urea (free diameter 5.2 A) is like Sieve A (free diameter of windows 4.3 A) in accommodating n- but not isoparaffins. Thiourea (6.1 A) and offretite (6.3 A) have channels with similar free diameters as do 0-cyclodextrin (7-8 A) and zeolite L (7.1 X 7.8 A). In thiourea the loose fit of n-paraffins in the tunnel appears to destabilize the adducts (85, 36). The same is true of disc-shaped molecules comprising only benzenoid rings. However, if suitably bulky saturated side chains are attached (cyclohexyl-benzene or fertf-butylbenzene), then adduction readily occurs. Heterocy-clics, like unsubstituted aromatics, do not readily form adducts. Thus flat molecules also exert a destabilizing effect upon the tunnels of a circular cross section. Such stability problems do not arise with the robust, permanent zeolite structures, and this constitutes an interesting distinction. Offretite, for example, readily sorbs benzene or heterocyclics with or without alkyl side chains, provided only that they are not too large to permeate the structure.

Aresta and Quaranta studied the reactivity of alkylammonium N-alkylcarbamates (RNH3)02CNHR towards a different acylating substrate, such as dimethyl carbonate (DMC) [62a, b]. Carbamate salts (RNH3)02CNHR (R = benzyl, allyl, cyclohexyl), prepared in situ from aliphatic primary amines and C02, reacted with DMC to afford N-alkyl methylcarbamates (Equation 6.6). The reaction requires mild conditions (343-363 K 0.1 MPa C02 pressure) and can be carried out in DMC used as solvent and reagent. At 363 K, carbamate esters were obtained in satisfactory yield (45-92%) with high selectivity, as side products such as ureas, N,N-dialkylcarbamate esters, and alkylated amines were formed in very small amounts. 

Polymer-immobilized nanogold catalysts promote very efficiently the synthesis of symmetric disubstituted ureas (RNH)2CO (R = alkyl), with a turnover frequency (TOF) of up to 3000 IT1 [132], After 20h at 453 K, the reactions of C02 (5 MPa) with cyclohexyl- or benzylamine gave the corresponding disubstituted ureas in 85% and 83% yields, respectively. 

Nl - UREA, 1-CYCLOHEXYL-3-( (p-( 2-( 5-METHYL-3-ISOXAZOLECARBOXAMIOO1 ETHYL 1 PHENYL ISULFONYL >-... 

CN ( )-/V-cyclohexyl-An-[4-[3-(( 1,1 -dimethylethyl)aminol-2-hydroxypropoxy]pheny)]urea monohydrochloride... 

Cyclohexene 1.2 dicarboximide tetramethrin Cyclohexene oxide propargite Cyclohexyl aldehyde triapenthenol Cyclohexyl amine hexazinone, hexythiazox Cyclohexyl hydroxylamine furmecyclox Cyclohexyl magnesium bromide cyhexatin Cyclohexyl magnesium chloride cyhexatin Cyclohexyl urea lenacil... 

Wu [5] prepared co-urea polyisoprene copolymers consisting of polyisopre-nediamines with 4-methylene-bis(cyclohexyl isocyanate). 

In addition to DCC and EDC many other aliphatic carbodiimides are used in peptide synthesis. Examples include N-t-butyl-N -methylcarbodiimide (BMC), N-t-butyl-N -ethylcarbodiimide (BEC), N,N -dicyclopentylcarbodiimide andN-cyclohexyl-N -isopropylcarbodiimide (CIC). DCC, diisopropylcarbodiimide, BMC and BEC perform similarly in peptide synthesis. " N-cyclohexyl-N -isopropylcarbodiimide (CIC) is comparable or even better than DCC for mediation of peptide bond formation in sohd phase synthesis. Also, the solubility of the derived urea in dichloromethane is useful in the standard procedure. " ... 

SYNS BELUSTINE CCNU CECENU CEENU CHLOROETHYLCYCLOHEXYLNITROSOUREA N-(2-CHLOROETHYL)-N -CYCLOHEXYL-N-NITROSOUREA (CHLORO-2-ETHYL)-l-CYCLOHEXYL-3-NITROSOUREA CINU (CLORO-2-ETIL)-l-CICLOESIi 3-NITROSO-UREA (ITALIAN) ICIG 1109 LOMUSTINE NCI-C04740 NSC-79037 RB 1509 SRI 2200... 

A somewhat different mechanism was deduced by Baker and Bailey 4f) from their own studies of the systems phenyl isocyanate and ethyl p-aminobenzoate (benzocaine) cyclohexyl isocyanate and aniline phenyl isocyanate and aniline p-methoxyphenyl isocyanate and aniline. While Craven postulates one complex. Baker and Bailey assume two complexes of the isocyanate one with the amine, and one with the product urea. 

A reagent which allows both CGA and HGA esterifications is DCC (dicyclohexylcarbodiimide 53 R = cyclohexyl). CGA esterifications are accomplished by treating a mixture of the carboxylic acid and the alcohol with DCC in hexane or pyridine with a catalytic amount of p-TsOH. The O-acylisourea (54) is postulated as intermediate, which reacts with the alcohol under elimination of the urea (56) and formation of the desired ester. The urea is removed by filtration (equation 22). This method is highly recom-mendable if both the carboxylic acid and the alcohol are valuable and bear sensitive functional groups. Numerous applications in natural product synthesis have been reported. ... 

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