Uracil group

Inaki (1992) synthesized a wide range of nucleobase-functionalized random and homopolymers. In addition, Inaki et al. (1980) synthesized block copolymers containing thymine and uracil groups in the main chain through ring-opening cationic and anionic polymerization of cychc derivatives of the nucleobases. 

The template polymerization was carried out at GO C in dimethyl sulfoxide/ethylene glycol mixture using AIBN as radical initiator. It was found that under these conditions interaction between adenine and uracil groups is remarkable. 

Figure 3.2 Template polymerization of monomer with uracil groups.

The polycomplex obtained by template polymerization of polyacrylamide with uracil groups onto template, from polyacrylamide with adenine groups, was found to be very stable compared with the polymer complex which was formed by mixing both polymers... 

The cage structure 6 is composed of two face-to-face porphyrins linked at both sides via six hydrogen bonds to two triaminopyridine entities. The distance between the cofacial porphyrins is estimated to be 10 A. The initial nieso 5,15-diuracil-substituted porphyrin has two rotameric forms, a syn and an anti, due to the relative orientations of the two uracil groups with respect to the porphyrin plane. In the self-assembling process, the syn rotamer yielded the major component, the cage structure, whereas the anti conformer yielded a zig-zag strand structure. As for the properties expected by such systems, metalation of one of the porphyrins allows for the creation of a self-assembled donor-acceptor system while complexation of the porphyrins with zinc(Il) allows for the cage cavity to be used as a... 

Monomer with uracil groups Polymer with adenine groups pyridine AIBN 42... 

Polymer 17U was composed of uracil-1-yl furanoid as hydrophobic and di-carboxydimethylene as hydrophilic groups. The carboxyl groups of the polymer in an aqueous solution protruded outward interacting with the aqueous environment. Consequently, the polymer had a conformation such that the chromophores aggregated into head-to-tail order in H2O to cause the hyper-chromicity. On the other hand, the uracil groups in the polymer were stacked one upon another in DMF to cause hypochromicity, which was also consistent with the fact that the UV extinction of the polymer in DMF was about half of that in H2O. 

It is the parent substance of a group of compounds which includes cytosine, thymine and uracil, which are constituents of nucleic acids and barbituric acid and its derivatives, which are important medicinally. 

Fluorinated Heterocyclic Compounds. HeterocycHc compounds containing the CF group are prepared by methods similar to those used in the fluorination of aHphatic compounds. The direct action of fluorine on uracil yields the cancer chemotherapy agent, 5-fluorouracil [51-21-8] as one special example of a selective fluorination on a commercial scale (25). 

Having a 5-methyl group, thymine is not nitrated or halogenated normally, but with aqueous bromine it does give the dihydropyrimidine (948) (25JBC(64)233) its other reactions parallel those of uracil although its behavior on irradiation is somewhat different (Section 2.13.2.1.4). 

The photochemical introduction of a trifluoromethyl group into aromatic and heteroaromatic rings, such as uracil, can be performed also with trifluoromethyl bromide [/5/] (equation 131)... 

FIGURE 11.28 The 5-methyl group on thymine labels it as a special kind of uracil. 

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