University of Rochester Medical Center

David G. Hicks, Professor and Director, Surgical Pathology Unit, Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY... 

University of Rochester Medical Center 601 ElmwoodAve., Rm. G-3275 PO. Box 321 Rochester, NY 14642... 

Mark J. Utell, University of Rochester Medical Center, Rochester, NY... 

Division of Medical Humanities University of Rochester Medical Center Rochester, New York... 

Rate of development of anticancer drugs by the national cancer institute and the U.S. pharmaceutical industry and the impact of regulation. In Final Report for the National Cancer Institute, University of Rochester Medical Center New York, 1981 40. 

Zubrod, C.G. Schepartz, S. Leiten, J. Endicott, K.M. Carrese, L.M. Baker, C.E. Cancer Chemotherapy Reports October 1996, 50 (7) DHEW Washington, DC, 1968. Rate of Development of Anticancer Drugs by the National Cancer Institute and the U.S. Pharmaceutical Industry and the Impact of Regulation. Final Report for the National Cancer Institute University of Rochester Medical Center New York, 1981 40. 

Fig. 22. Male peripheral blood mononuclear cells labeled with biotin- l chromosome probe/avidin (F1TC green) and counterstained with propidium iodide (red). Seventeen optical sections (27 x 27/zm each) were imaged at 0.2

In a critical study at the University of Rochester Medical Center in New York, researchers directly linked chemotherapy to brain cell death in humans and rodents. Biomedical geneticist Mark D. Noble, Ph.D., and his colleagues reported that three chemotherapy drugs commonly used to treat cancer (carmustine, cisplatin, and cytara-bine) may be more toxic to healthy brain cells than to the cancer cells they are meant to destroy. They cultured human brain cells after exposing them to the drugs and also looked at how multiple human cancer cell lines, such as uterine and breast, reacted to the compounds. They found that typical doses of these drugs killed 70 to 100 percent of the brain cells but just 40 to 80 percent of the cancer cells. 

Leo G. Abood, Ph D., was Professor of Pharmacology, Department of Pharmacology and Physiology, University of Rochester Medical Center until his death in January 1998. Dr. Abood was an expert on the biochemistry and physiology of the nervous system whose research focused on the isolation and characterization of neurotransmitter receptors from the mammalian brain, specifically nicotine, vasopressin, and opioid receptors. He previously served on the NRC Committee on Toxicology s Panel on Anticholinergic Compounds and the Chemical Weapons Stockpile Assessment Panel. 

Department of Psychiatry and Division of Genetics University of Rochester Medical Center Rochester, New York 14642 Department of Medicine The University of Chicago 5847 Maryland Avenue Chicago, Illinois 60637... 

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