Unified strategy

Oltra and Cuerva have reported a unified strategy for the synthesis of the eudesmanolides that relies on the collidine-chlorotrimethylsilane reagent... 

Ciufolini, MA. Shm, Y.-C. Bishop, M.J. (1995) A unified strategy for the synthesis of sulfur-containing pyridoacridine alkaloids antitumor agents of marine origin. J. Am. Chem. Soc., 117,12460-9. 

Feldman KS, Saunders JC, Wrobleski ML (2002) Alkynyliodonium Salts in Organic Synthesis. Development of a Unified Strategy for the Syntheses of (-)-Agelastatin A and (-)-Agelastatin B. J Org Chem 67 7096... 

For an outline of an alternative unified strategy for the synthesis of aryl C-glycosides, see Martin, S. F. Pure AddI. Chem. 2003. 75, 63. 

In the evolution of QSAR models for ecotoxicity, several pathways have been addressed, to better explore the possibilities. The numerous QSAR models (many thousands) have been in some cases organized within a unified strategy of developing an architecture in which several simple models are present. In other cases global models have been developed by way of more... 

There are no grand unifying strategies to make 1,2-disubstituted compounds. Rather there are many diverse methods which I sha]] try to classify in a helpful fashion. Here, even more than elsewhere, it is important to judge each case on its merits. One common theme is a preference for the disconnection (1) of the bond joining the two substituted atoms. 

It is also worth mentioning that mathematical modeling of the process and combustion chamber was so reliable that it could be employed as a powerful design tool to optimize the combustion system avoiding expensive trials (Figure 23.23). Then modeling could be used in conjunction with experiments in a unified strategy for... 

Bisai A, West SP, Sarpong R (2008) Unified strategy for the synthesis of the miscellaneous Lycopodium alkaloids total synthesis of ( )-lyconadin A. J Am Chem Soc 130 7222-7223... 

An interesting Csp -Csp coupling via an aryl radical cyclization has been used as the key step in a unified strategy to synthesize vasconine (22), assoanine (20), oxoassoanine (21), and pratosine. Tin hydride cyclization of an A-(o-bromobenzyl)-aniline yielded a substituted phenanthridine which was subsequently transformed into vasconine (22), from which the remaining natural products were prepared (269) (Scheme 9). 

Gross U, Nieger M, Brase S (2010) A Unified Strategy Targeting the Thiodiketopiperazine Mycotoxins Exserohilone, Gliotoxin, the Epicoccins, the Epicorazines, Rostratin A and Aranotin. Chem Eur J 16 11624... 

Brohmer MC, Bourcet E, Nieger M, Brase S (2011) A Unified Strategy for the Asymmetric S mthesis of Diversonol and Lachnone C. Chem Eur J 49 13706. 

Stark, S., Chernyshenko, O S. and Drasgow, F. 2006. Detecting differential item functioning with confirmatoiy factor analysis and item response theory Toward a unified strategy. Journal of Applied Psychology, 91(6), 1292-306. 

Dickie, R. A., Toward a Unified Strategy of Service Life Prediction, Journal of Coatings Technology, Vol. 64, No. 809, June 1992, pp. 61-64. 

In 2011, Yang and coworkers developed a unified strategy for the synthesis of drimane-type sesquiterpenoids based on an enabling gold-catalyzed tandem reaction (Scheme 13.26) [31], This strategy accomplished the first total synthesis of maras-mene and other analogs of drimane-type sesquiterpenoids. 

Breder A, Chinigo GM, Waltman AW et al (2011) Towards the synthesis of massadine a unified strategy for the stereoselective synthesis of the carbocyclic c, d-ring subunit. Chem Eur J 17 12405-12416... 

GalUgan MJ, Akula R, Ibrahim H (2014) Unified strategy for iodine(III)-mediated halogenation and azidation of 1,3-dieaibonyl eompounds. Org Lett 16(2) 600-603... 

FIGURE 12.3 A unified strategy for alkaloid synthesis completed and almost completed alkaloids... 

As will be discussed, our pivotal intramolecular aza-[3+3] cycloaddition was remarkably efficient in providing the tricyclic scaffold of (—)-cylindricine C 384 and that of putative (—)-lepadiformine 389 (or (—)-4-deoxo-2-epi-cylindricine C) [170b,[198], yet this route could not be implemented in our synthesis of (—)-lepadiformine 385. To reconcile this, we devised a unified strategy to synthesize (—)-lepadiformine and (+)-cylindricines C-E (386-388) that... 

To advance our quest in demonstrating the utility of our pivotal intramolecular aza-[3+3] cycloaddition as a unified strategy to access different Wheterocyclic manifolds known in naturally occurring alkaloids, we synthesized the family of Coccinellidae defensive alkaloids 420 and 426-429 (Figure 12.5) [171]. Our strategy utilizes a common intermediate, the aza-tricyclic core 425, which is attained via an intramolecular aza-[3+3] cycloaddition. 

After our puhhcation of our unified strategy toward (+)-cylindricines C—E and (—)-lepadiformine, Kibayashi published their strategy. See Ref. [201d]. 

Trost BM, MaUiotra S, Chan WH. Exercising regiocontrol in palladium-catalyzed asymmetric prenylations and geranyla-tion unifying strategy toward flustramines A and B. J. Am. Chem. Soc. 2011 133(19) 7328-7331. 

Reiss T, Breit B. A unified strategy for the stereospecific construction of propionates and acetate-propionates relying on a directed allylic substitution. Chem. Eur. J. 2009 15 6345-6348. 

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