Unicellular parasites

Conduction disturbances are frequently found in acute and chronic Chagas disease. In cultures of neonatal rat hearts, changes in the gap junction distribution were studied to discover whether they were associated with the infection. In cultured cardiomyocytes infected with the unicellular parasite Trypanosoma cruzi responsible for Chagas disease, which is the most common cause of heart disease in South America, reduced gap junctional conductance... 

Extracts of baobab root are trypanocidal to either Trypanosoma brucei brucei and T. congolense. T. brucei brucei and T. congolense are unicellular parasites transmitted by the bites of tsetse fly and is the causative agent of sleeping sickness in humans and related diseases in animals (27). 

Find the target. Trypanosomes are unicellular parasites that cause sleeping sickness. During one stage of their life cycle,... 

As the only unicellular parasite to live free in the host s bloodstream the African, or salivarian, trypanosomes are unique. Unfortunately, there is little information on African trypanosome lipids and lipid metabolism. The life cycle of the African trypanosome involves bloodstream forms in the mammalian host and various insect forms in the tsetse fly vector. Of the insect forms, only the in vitro propagated procyclic form, equivalent to those in the tsetse fly midgut, has been examined. Early studies used complex culture medium that contained significant exogenous lipid. Later studies used... 

A striking feature of P. falciparum, the unicellular parasite responsible for the most virulent and widespread form of human malaria, is that it hosts the GC-poorest (22% GC) nuclear genome known so far (Poliak et al., 1982, McCutchan et al., 1984). This genome, which only comprises 3 Mb of DNA (Weber, 1988) organized in 14 chromosomes (Kemp et al., 1987 Wellems et al., 1987), is, therefore, an excellent model for studying compositional constraints and their effects. 

These faculties have been preserved in most free living extant unicellular eukaryotes (Amoebae, the Naegleria, or the kinetoplasts), but became lost in multicellular orgaiusms, except for their gonads. The unicellular parasites (plas-modia, trypanosoma, theileria) possess an RNA/DNA complex genome that could... 

The Cancer Cell Viewed as an Ancient Unicellular Parasite (an Amoeba)... 

Even in the Molecular Era, It Still Looks like an Amoeboid Unicellular Parasite... 

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