Even in the Molecular Era, It Still Looks like an Amoeboid Unicellular Parasite

Even in the Molecular Era, It Still Looks like an Amoeboid Unicellular Parasite 

Johnston, S.B. Pai and R.B. Pai in the era of advancing biochemistry, wrote ...many workers have independently commented on the similarities observed between the behaviors displayed by dedifferentiated cancer cells and their embryonic precursors. ...Cancer ceUs behave in ways that are reminiscent of primitive eukaryotic ceUs. Cancer ceUs might be considered to represent, with their loss of tumor suppressor inhibitory activity and elevation of oncogene stimulatory activity, a reversion to a more primitive evolutionary state capable of indeterminate growth at the expense of the host. By this analogy, the growth phenotypes displayed by cancer ceUs, embryonic ceUs, and free-hving eukaryotes 

Presumably, intron loss occurred in the time interval elapsing between the eumetazoan ancestor and the appearance of the common ancestor of choanoflagellates and metazoans in the Precambrian sea over 600 years ago. Protein domains PFAM and SMART (containing 685 hidden Markov models, http/Zsmart.embl-heidelberg) 

The uninuclear, hierarchial Amoebozoans, with the ability to form syncytia [2271], which crawl and phagocytose (cell cannibalism) appears to be the direction toward which the cells (de-differentiating stem or somatic cells) descend on the evolutionary scale during their so called malignant transformation . In nature, under natural circumstances, among the extant descendents of the ancient unicellular eukaryotes, it is not possible to readily find colonies that would resemble that of the HeLa cells. Under adverse circumstances, as in the Hydractinia colony, it may happen that de-differentiated cells overgrow the colony. 

Mutator features appear first in the archaea. The anaerobic crenarchaeon, Pyrobaculum aerophilum lives in boiling marine water holes. Its mRNA does not express 5 imtranslated regions, therefore its protein translation is initiated without a ribosome binding site ( leaderless transcripts ). It synthesizes carbohydrates through 

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