Understanding Properties and Reactivity Related to Physiology

Along with research on the physical and chemical properties of nanomaterials, simnltaneous and coordinated research is needed on their physiological properties, and any associated enviromnental, health, and safety risks. At the nanoscale, research must address the correlation between factors such as particle size, shape, surface charge, area, and reactivity and potential toxicological risks. 

Different methods of delivery of nanotechnology-enabled CB weapons wiU likely require different countermeasures. Delivery via aerosol, food, water, or skin will potentially elicit different physiological and biological reactions and wiU require different treatments. For example, prions and other proteins may be able to attach to nanoenabled aerosol particles that have the capability to cross the blood-brain barrier. Research to understand delivery mechanisms for prions, levels of infectious doses, and overall time dependence is needed. 

Selective bioaccumulation, or an accumulation process in which biological sequestering resnlts in a higher concentration of a substance in one location, is 

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