Ubiquitin associated domain

Kleijnen, M. F., Alarcon, R. M., and Howley, P. M. The ubiquitin-associated domain of hPLIC-2 interacts with the proteasome. Mol Biol Cell 2003, 34, 3868-75. 

Rao, H. and Sastry, A. Recognition of specific ubiquitin conjugates is important for the proteolytic functions of the ubiquitin-associated domain proteins Dsk2 and Rad23./. Biol. Chem. 2002, 277, 11691-11695. 

Rassi, S. and Pickart, C. M. Rad23 ubiquitin-associated domains (UBA) inhibit 26S proteasome-catalyzed proteolysis by sequestering lysine 48-linked polyubiquitin chains. J. Biol. Chem. 2003, 278, 8951-8959. 

FI/F2/F3, triad of RING-finger-like domains F, F-box domain USP, deubiquitinase catalytic domain OTU, a particular class of cystein protease domains RVP, retroviral protease domain DBA, ubiquitin-associated domain Pkinase, protein kinase catalytic domain. 

Fig. 1 The human IAP protein family. Human IAP proteins contain one or three baculovirus IAP repeat (BIR) domains. Several IAP family members also have RING (really interesting new gene) and UBA (ubiquitin associated) domains. The c-IAPl and C-IAP2 proteins each contain a caspase recruitment domain (CARD). Survivin contains a coiled coil domain NAIP has NACHT (domain present in NAIP, CIITA, HET-E, TP1) and leucine rich repeat (LRR) domains Apollon possesses a ubiquitin conjugating (UBC) domain...

UBCl 215 [28] Unknown Hrdl [39] Short C-terminal tail harbors ubiquitin-associated (UBA) domain [155] Essential in ubc4Aubc5A genetic background, suggesting a redundant role with Ubc4/5 in proteasomal turnover of short-lived and abnormal proteins [28] Role in ERAD that is not fulfilled by Ubc4/5 [39, 40]... 

TtrapNT A further UBA-like domain is found at the N-terminus of the TNF- and TRAF-associated protein Ttrap, as well as a number of other sequences including eight other human proteins and the yeast ORF Ylrl28w. The scope of proteins harboring the TtrapNT domain resembles that of the UBA proteins. The Cezarme -like proteins combine the TtrapNT module with an OUT-type protease domain, while other proteins also contain UIM or UBX domains. Most TtrapNT proteins have an established or predicted role in the ubiquitin pathway, making it likely that TtrapNT serves as a recognition module for ubiquitin or ubiquitin-like domains. 

Madura, K., The ubiquitin-associated (UBA) domain on the path from prudence to prurience. Cell Cycle,... 

T. G., and Madura, K., Ubiquitin-associated (UBA) domains in Rad23 bind ubiquitin and promote inhibition of multi-ubiquitin chain assembly, EMBO Rep., 2001, 2, 933. 

Ubiquitin binding associated domain, one class of ubiquitin binding domains... 

The biologic function of Ras is mediated by its ability to activate downstream cytoplasmic signaling networks through binding to a panel of effector proteins. The Ras-effector interaction is mediated through interactions between the core effector domain (amino acids 32 0) of Ras (see Fig. 2) and the specific residues within the Ras-binding domain (RBD) or Ras-association domain (RA) found in most Ras effector proteins. The RBDs and RA domains of effector proteins do not exhibit primary sequence homology, but instead they share a common tertiary structure that consists of an ubiquitin superfold, which forms critical contacts with Ras (33). 

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