Tyrosine kinase-mediated signalling

Songyang, Z. and Cantley, L.C. Recognition and specificity in protein tyrosine kinase-mediated signalling (1995) Trends Bioch. Sci. 20, 470-475... 

Table 8.3 Receptor tyrosine kinase-mediated signalling ...

Andrechek, E. R. and Muller, W. J. (2000). Tyrosine kinase signalling in breast cancer tyrosine kinase-mediated signal transduction in transgenic mouse models of human breast cancer. Breast Cancer Res 2(3) 211-6. 

Figure 2 Potential tyrosine kinase-mediated signaling pathways for silica.

The transformation of rodent fibroblasts by a variety of tyrosine kinase oncogenes also causes chronic elevation of Ras-GTP levels. It thus seems obvious that Ras proteins ate essential components of tyrosine kinase mediated rtritogenic signaling pathways. Ras proteins are activated in response to a wide variety of extracellular stimuli that activate receptor and receptor-associated tyrosine kinases TKs). 

Alternatively, the release of platelet phospholipid AA is mediated by the activation of phospholipase Aj (PIA) coupled to PLC, intracellular Ca rise and protein kinase C (PKC) and tyrosine kinase-mediated protein phosphorylations (23,24) and/or by the activation of PLA that is not coupled to these events in platelets (25-29). Furthermore, the hydrolysis of phosphatidic acid (PA) by a PA-specific PLAj may also contribute to eicosanoid synthesis (30,31). It is evident that the differential sensitivity of platelets to multiple agonists and their signals, have contributed to the complexity in understanding the regulation of PLAj. 

Canesi, L., C. Ciacci, M. Betti, A. Scarpato, B. Citterio, C. Pruzzo and G. Gallo. Effects of PCB congeners on the immune function of Mytilus hemocytes alterations of tyrosine kinase-mediated cell signaling. Aquat. Toxicol. 63 293-306, 2003. 

CANESi L, BETTI M, ciAcci c, GALLO G (2001), Insulin-like effect of zinc in mytilus digestive gland cells modulation of tyrosine kinase-mediated cell signaling. Gen Com Endocrinol, 122, 60-66. 

Ephrins are a group of membranous ligands, which function through a family of receptor tyrosine kinases (Ephs). Ephrin/Eph-mediated signaling processes are involved in morphogenetic processes taking place e.g. during the development of the nervous system or the vasculature. 

Fyn is a nonreceptor tyrosine kinase related to Src that is frequently found in cell junctions. Die protein is N-myristoylated and palmitoylated and thereby becomes associated with caveolae-like membrane microdomains. Fyn can interact with a variety of other signaling molecules and control a diversity of biological processes such as T cell receptor signaling, regulation of brain function, and adhesion mediated signaling. 

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