Tyrianthins

Merremosides B (13) and D (15) exhibited antiserotonergic activity in mice with Dgo values of 10 pg/cm and 2 pg/cm, (c/., promethazine, Dgo 2 pg/cm ) (24). Intraperitoneal administration to mice of tyrianthins VI (91), VIII (scammonin VI, 68), and IX (93) resulted in antidepressant activity. Also, the activities of tryanthi-nic acids I (94) and II (95), and the macrolactones scammonins I (63) and II (64), and tyrianthins VI (91), VIII (68), and IX (93) exhibited dose-dependent protective effects against pentylenetetrazole-induced seizures. Tyrianthin VI (91) and scammonin II (64) produced relaxant effects on spontaneous contractions in the isolated rat ileum. Finally, the administration of compounds 68 and 93-95 to mouse brain slices induced increments in the release of GABA and glutamic acid 48). 

Leon-Rivera I, Miron-Lopez G, Molina-Salinas GM, Herrera-Ruiz M, Estrada-Soto S, Gutierrez M, Alonso-Cortes D, Navarrete-Vasquez G, Rios M, Said-Femandez S (2008) Tyrianthinic Acids from Ipomoea tyrianthina and Their Antimycobacterial Activity, Cytotoxicity and Effects on the Central Nervous System. J Nat Prod 71 1686... 

CHjCJj-SP tyrianthins 1 - 7 orizabins I, XVIII scammonins I, II stansins 3, 5... 

Miscellaneous Effects. Recently, tyrianthin 6 was demonstrated (i) to result in antidepressant activity (mice, i.p.), (ii) to exhibit dose-dependent protective effects against pentylenetetrazole-induced seizures, and (iii) to produce relaxant effects on... 

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